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dc.contributor.authorWOLFE, KENNETH
dc.date2005en
dc.date.accessioned2009-04-15T17:21:27Z
dc.date.available2009-04-15T17:21:27Z
dc.date.issued2005
dc.date.submitted2005en
dc.identifier.citationSinger, G. A. C., Lloyd, A. T., Huminiecki, L. B. and Wolfe, K. H. `Clusters of co-expressed genes in mammalian genomes are conserved by natural selection? in Molecular Biology and Evolution 22, (3), 2005, pp 767-775en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/29227
dc.descriptionPUBLISHEDen
dc.description.abstractGenes that belong to the same functional pathways are often packaged into operons in prokaryotes. However, aside from examples in nematode genomes, this form of transcriptional regulation appears to be absent in eukaryotes. Nevertheless, a number of recent studies have shown that gene order in eukaryotic genomes is not completely random, and that genes with similar expression patterns tend to be clustered together. What remains unclear is whether co-expressed genes have been gathered together by natural selection to facilitate their regulation, or if the genes are co-expressed simply by virtue of their being close together in the genome. Here, we show that gene expression clusters tend to contain fewer chromosomal breakpoints between human and mouse than expected by chance, which indicates that they are being held together by natural selection. This conclusion applies to clusters defined on the basis of broad (housekeeping) expression, or on the basis of correlated transcription profiles across tissues. Contrary to previous reports, we find that genes with high expression are not clustered to a greater extent than expected by chance and are not conserved during evolution.en
dc.format.extent763071 bytes
dc.format.extent767-775en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.ispartofseriesMolecular Biology and Evolutionen
dc.relation.ispartofseries22en
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectgenome organizationen
dc.subjecthuman genomeen
dc.subjectmouse genomeen
dc.subjectnatural selectionen
dc.titleClusters of co-expressed genes in mammalian genomes are conserved by natural selectionen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/khwolfe
dc.identifier.rssinternalid35975
dc.identifier.rssurihttp://dx.doi.org/10.1093/molbev/msi062


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