Browsing School of Genetics & Microbiology by Author "MARIN MENENDEZ, ALEJANDRO"
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A family of cyclophilin-like molecular chaperones in Plasmodium falciparum
MARIN MENENDEZ, ALEJANDRO; BELL, ANGUS (2012)The cyclophilins are a large family of proteins implicated in folding, transport and regulation of other proteins and are potential drug targets in cancer and in some viral and parasitic infections. The functionality of ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
BELL, ANGUS; MARIN MENENDEZ, ALEJANDRO (BioMed Central, 2010)Cyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. Cyclophilins play roles in folding and chaperoning ... -
Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum
BELL, ANGUS; MARIN MENENDEZ, ALEJANDRO (2011)Malaria represents a global health, economic and social burden of enormous magnitude. Chemotherapy is at the moment a largely effective weapon against the disease, but the appearance of drug-resistant parasites is reducing ...