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  • Exploring the functions of PRC2 in development and congenital disorders 

    Deevy, Orla (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)
    Polycomb group (PcG) proteins are key chromatin-based repressors of gene expression that play important roles in lineage-specification and cellular memory. PcG proteins assemble into multi-subunit complexes, termed Polycomb ...
  • PRC2 functions in development and congenital disorders 

    Bracken, Adrian; Deevy, Orla (2019)
    Polycomb repressive complex 2 (PRC2) is a conserved chromatin regulator that is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for normal development and its loss of function thus results ...