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dc.contributor.authorGARAVAN, HUGH PATRICK
dc.date.accessioned2008-11-19T15:31:05Z
dc.date.available2008-11-19T15:31:05Z
dc.date.issued2003
dc.date.submitted2003en
dc.identifier.citationLawrence NS, Ross TJ, Hoffmann R, Garavan H, Stein EA `Multiple neuronal networks mediate sustained attention? in Journal of Cognitive Neuroscience, 15, (7), 2003, pp 1028 - 1038en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/24860
dc.descriptionPUBLISHEDen
dc.description.abstract& Sustained attention def icits occur i n several neuropsychi- atric di sorders. However, the underlying neurobiol ogical mechani sms are stil l i ncompletely understood. To that end, f unctional MRI was used to investi gate the neural substrates of sustained attention (vigil ance) usi ng the rapid vi sual i nformation processi ng (RVIP) task in 25 healthy vol unteers. In order to better understand the neural networks under- l yi ng attentional abil ities, brai n regions where task-induced acti vati on correlated wi th task perf ormance were i denti fi ed. Perf ormance of the RVIP task activated a network of frontal, parietal, occipital, thal amic, and cerebell ar regi ons. Deacti va- ti on during task perf ormance was seen in the anterior and posteri or ci ngul ate, i nsul a, and the l ef t temporal and parahippocampal gyrus. Good task performance, as def ined by better detection of target stimul i, was correl ated with enhanced acti vati on i n predomi nantly right fronto-parietal regi ons and with decreased activation in predominantl y lef t temporo-l imbi c and cingulate areas. Factor analysi s revealed that these performance-correlated regions were grouped i nto two separate networks compri sed of positively acti vated and negatively activated i ntercorrelated regi ons. Poor perf ormers f ail ed to signif icantly acti vate or deactivate these networks, whereas good performers either acti vated the positi ve or deactivated the negative network, or did both. The f act that both increased activation of task-specifi c areas and increased deactivati on of task- irrelevant areas mediate cogniti ve f unc- ti ons underlying good RVIP task perf ormance suggests two i ndependent circuits, presumably ref lecting diff erent cogni - ti ve strategi es, can be recruited to perform this vigilance task.en
dc.format.extent1028en
dc.format.extent1038en
dc.format.extent479725 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherMIT Pressen
dc.relation.ispartofseriesJournal of Cognitive Neuroscienceen
dc.relation.ispartofseries15en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectPsychologyen
dc.titleMultiple neuronal networks mediate sustained attentionen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanh
dc.identifier.rssinternalid39199


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