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dc.contributor.authorMURPHY, PAULA
dc.date.accessioned2008-11-06T13:05:27Z
dc.date.available2008-11-06T13:05:27Z
dc.date.issued2008
dc.date.submitted2000en
dc.identifier.otherY
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/23999
dc.descriptionPUBLISHEDen
dc.description.abstractIn amniotes, myogenic commitment appears to be dependent upon signaling from neural tube and dorsal ectoderm, that can be replaced by members of the Wnt family and by Sonic hedgehog. Once committed, myoblasts undergo different fates, in that they can differentiate immediately to form the myotome, or later to give rise to primary and secondary muscle fibers. With fiber maturation, satellite cells are first detected; these cells contribute to fiber growth and regeneration during post-natal life. We will describe recent data, mainly from our laboratory, that suggest a different origin for some of the cells that are incorporated into the muscle fibers during late development. We propose the possibility that these myogenic cells are derived from the vasculature, are multi-potent and become committed to myogenesis by local signaling, when ingressing a differentiating muscle tissue. The implications for fetal and perinatal development of the whole mesoderm will also be discussed.en
dc.format.extent699en
dc.format.extent706en
dc.format.extent202770 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesInternational Journal of Developmental Biologyen
dc.relation.ispartofseries44en
dc.rightsYen
dc.subjectMyogenic determinationen
dc.subjectmyogenic lineagesen
dc.subjectsatellite cellsen
dc.subjectmultipotent progenitorsen
dc.titleDetermination, diversification and multipotency of mammalian myogenic cellsen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pmurphy3
dc.identifier.rssurihttp://www.ijdb.ehu.es/web/paper.php?doi=11061434&a=f


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