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  • Factors affecting paclitaxel content in yew 

    Dempsey, Dairine (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)
    The anti-cancer agent paclitaxel has been the subject of intense scientific evaluation since it was first isolated from the bark of the Pacific yew [T. brevifolia] in 1971. It is currently used extensively in the treatment ...
  • Synthesis and pharmacological studies on a novel series of mast cell-stabilising tetrahydronaphthalenes and related compounds 

    Barlow, James William (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)
    The purpose of this thesis was the design, synthesis and pharmacological screening of a novel series of tetrahydronapthalene molecules for mast cell-stabilising activity. The introductory Chapter commences with a discussion ...
  • Design, synthesis and in vitro evaluation of novel anti-cancer compounds 

    McCormack, Emmet Martin (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)
    The purpose of this thesis was the design, synthesis and in vitro appraisal of a novel class of ITP/APN dual inhibitory compounds. Additionally, a class of novel biaryls, which were synthesised within the research group, ...
  • The design and synthesis of novel inhibitors of tubulin polymerisation 

    Shah, Richard (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)
    This thesis is introduced with a review on the principles of tubulin polymerisation and how this process is necessary for cellular replication. This leads on to discussion of the structure-activity relationships of known ...
  • Production of quinones by in vitro cultures of Dionaea and Streptocarpus species 

    Nestor, Cora (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)
    Quinones are a class of oxygen-containing secondary metabolites found chiefly in higher plants, fungi, bacteria and restricted in the animal kingdom to arthropods and echinoderms (Thompson 1971). In the plant, quinones, ...
  • Chemical and morphological variability of Taxus : needles, seeds and cell cultures 

    Visdal-Johnsen, Lene (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)
    The genus Taxus (family Taxaceae) has during the last 30-40 years been the subject of extensive scientific investigation due to the discovery of the anti-cancer drug paclitaxel (Taxol) originally isolated from the bark of ...
  • Chemical and pharmacological studies on pereskia bleo Kunth. (Cactaceae) and choisya ternata Kunth. (Rutaceae) 

    Abdul Wahab, Ikarastika Rahayu (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)
    Phytochemical and pharmacological investigations of Pereskia bleo (Kunth) DC (Cactaceae) and Choisya ternata Kunth. (Rutaceae) fractions were carried out. The chemical evaluation of P. bleo fractions resulted in the isolation ...