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  • Factors affecting paclitaxel content in yew 

    Dempsey, Dairine (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)
    The anti-cancer agent paclitaxel has been the subject of intense scientific evaluation since it was first isolated from the bark of the Pacific yew [T. brevifolia] in 1971. It is currently used extensively in the treatment ...
  • Production of quinones by in vitro cultures of Dionaea and Streptocarpus species 

    Nestor, Cora (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)
    Quinones are a class of oxygen-containing secondary metabolites found chiefly in higher plants, fungi, bacteria and restricted in the animal kingdom to arthropods and echinoderms (Thompson 1971). In the plant, quinones, ...
  • Synthesis and pharmacological studies on a novel series of mast cell-stabilising tetrahydronaphthalenes and related compounds 

    Barlow, James William (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)
    The purpose of this thesis was the design, synthesis and pharmacological screening of a novel series of tetrahydronapthalene molecules for mast cell-stabilising activity. The introductory Chapter commences with a discussion ...
  • The design and synthesis of novel inhibitors of tubulin polymerisation 

    Shah, Richard (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)
    This thesis is introduced with a review on the principles of tubulin polymerisation and how this process is necessary for cellular replication. This leads on to discussion of the structure-activity relationships of known ...