RSS 1.0Pharmacognosy (Theses and Dissertations)
Browse by
Recent Submissions
-
Chemical and morphological variability of Taxus : needles, seeds and cell cultures
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)The genus Taxus (family Taxaceae) has during the last 30-40 years been the subject of extensive scientific investigation due to the discovery of the anti-cancer drug paclitaxel (Taxol) originally isolated from the bark of ... -
The design and synthesis of novel inhibitors of tubulin polymerisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis is introduced with a review on the principles of tubulin polymerisation and how this process is necessary for cellular replication. This leads on to discussion of the structure-activity relationships of known ... -
Production of quinones by in vitro cultures of Dionaea and Streptocarpus species
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)Quinones are a class of oxygen-containing secondary metabolites found chiefly in higher plants, fungi, bacteria and restricted in the animal kingdom to arthropods and echinoderms (Thompson 1971). In the plant, quinones, ... -
Design, synthesis and in vitro evaluation of novel anti-cancer compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The purpose of this thesis was the design, synthesis and in vitro appraisal of a novel class of ITP/APN dual inhibitory compounds. Additionally, a class of novel biaryls, which were synthesised within the research group, ... -
Factors affecting paclitaxel content in yew
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The anti-cancer agent paclitaxel has been the subject of intense scientific evaluation since it was first isolated from the bark of the Pacific yew [T. brevifolia] in 1971. It is currently used extensively in the treatment ...
