Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Author "Crown, John"
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Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.
O'Driscoll, Lorraine; Eustace, Alex J.; Conlon, Neil T.; McDermott, Martina S.J.; Browne, Brigid C.; O'Leary, Patrick; Holmes, Frankie A.; Espina, Virginia; Liotta, Lance A.; O'Shaughnessy, Joyce; Gallagher, Clair; Rani, Sweta; Madden, Stephen F.; O'Brien, Neil A.; Ginther, Charles; Slamon, Dennis; Walsh, Naomi; Gallagher, William M.; Zagozdzon, Radoslaw; Watson, William R.; O'Donovan, Norma; Crown, John (2018)Background: Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to ... -
Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study
O'DRISCOLL, LORRAINE; Larkin, Annemarie; Kennedy, Susan; Purcell, Rachel; Moran, Elizabeth; Crown, John; Parkinson, Michael; Clynes, Martin (2004)The efficacy of breast cancer treatment is limited by the development of resistance to various chemotherapeutic agents. We conducted a retrospective study of the expression of 2 drug resistance efflux pumps, MRP‐1 and MDR‐1 ... -
Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer
O'Driscoll, Lorraine; Porter, Richard; Martinez, Vanesa G.; Crown, John (2017)Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to ... -
Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles
O'Driscoll, Lorraine; Martinez, Vanesa G.; O'Neill, Sadhbh; Salimu, Josephine; Breslin, Susan; Clayton, Aled; Crown, John (2017)Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family– plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall ...