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  • Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease 

    PIGOTT, MARIA THERESE (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)
    The aetiology of inflammatory bowel disease (IBD) is incompletely understood but it is generally accepted to involve a dysregulated intestinal immune response to commensal microbiota and an increase in intestinal permeability. ...
  • The production and characterisation of itraconazole multicomponent systems 

    KOZYRA, AGNIESZKA IRENA (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)
    This thesis focuses on the poorly soluble triazole antifungal agent, itraconazole (ITZ). This compound was reported to form hydrochloride salts and cocrystals with a wide range of aliphatic dicarboxylic acids, which have ...
  • The production and characterization of fluoroquinolone amorphous solid dispersions 

    MESALLATI, HANAH NADINE (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)
    Ciprofloxacin (CIP) is a Biopharmaceutics Classification System class 4 drug, which exhibits solid-state limited solubility. Among the different formulation options available to improve the solubility of such a compound, ...
  • The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles 

    MCCOMISKEY, KATE P.M (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)
    In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ...