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  • Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus 

    HUMPHRIES, PETER; PALFI, ARPAD; CHADDERTON, NAOMI SARAH; FARRAR, GWYNETH JANE; KENNA, PAUL (2012)
    Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted packaging capacity of approximately 5kb. To bypass this limita- tion, ...
  • Mitochondrial disorders: aetiologies, models systems, and candidate therapies 

    MILLINGTON-WARD, SOPHIA; CHADDERTON, NAOMI SARAH; FARRAR, GWYNETH JANE; KENNA, PAUL (2013)
    It has become evident that many human disorders are characterised by mitochondrial dysfunction either at a primary level, due to mutations in genes whose encoded products are involved in oxidative phosphorylation, or at a ...