Browsing Genetics (Scholarly Publications) by Author "CAMPBELL, MATTHEW"
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Blood-brain barrier regulation in psychiatric disorders
CAMPBELL, MATTHEW (2018) -
Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia
HUMPHRIES, PETER; CAMPBELL, MATTHEW; HUMPHRIES, MARIAN (2017)The juxtacanalicular connective tissue of the trabecular meshwork together with inner wall endothelium of Schlemm’s canal (SC) provide the bulk of resistance to aqueous outflow from the anterior chamber. Endothelial cells ... -
GlycoRDF: An ontology to standardize glycomics data in RDF
CAMPBELL, MATTHEW (2015)Motivation: Over the last decades several glycomics-based bioinformatics resources and databases have been created and released to the public. Unfortunately, there is no common standard in the representation of the stored ... -
Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
CAMPBELL, MATTHEW; FARRAR, JANE; KENNA, PAUL (2013)Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase ... -
Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension
HUMPHRIES, PETER; CAMPBELL, MATTHEW (2018) -
MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI
CAMPBELL, MATTHEW; KERSKENS, CHRISTIAN; CAMPBELL, MATTHEW; KERSKENS, CHRISTIAN MATTHIAS (2013)BACKGROUND AND PURPOSE: The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL ... -
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
FARRAR, JANE; KENNA, PAUL; KIANG, ANNA-SOPHIA; HUMPHRIES, MARIAN; HUMPHRIES, PETER; TAM, LAWRENCE; CAMPBELL, MATTHEW (2010)Retinitis pigmentosa (RP) is the most prevalent cause of registered visual handicap among working aged populations of developed countries. Up to 40% of autosomal dominant cases of disease are caused by mutations within the ... -
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
CAMPBELL, MATTHEW; DOYLE, SARAH (2015)The inflammasome is a molecular platform formed by activation of an innate immune pattern recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC (apoptosis-related speck-like protein ... -
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
FARRAR, JANE; HUMPHRIES, MARIAN; HUMPHRIES, PETER; CAMPBELL, MATTHEW (2008)Mutations within the inosine 5'-monophosphate dehydrogenase 1 (IMPDH1) gene cause the RP10 form of autosomal dominant retinitis pigmentosa (adRP), an early-onset retinopathy resulting in extensive visual handicap owing to ...