Browsing Genetics (Scholarly Publications) by Title
Now showing items 248-267 of 303
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Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.
(2008)Background: The trajectory of corticospinal tract (CST) axons from cortex to spinal cord involves a succession of choice points, each of which is controlled by multiple guidance molecules. To assess the involvement of ... -
Sensitivity of Photoreceptor-Derived Cell Line (661W) to Baculoviral p35, Z-VAD.FMK, and Fas-Associated Death Domain
(Association for Research in Vision and Ophthalmology, 2002)PURPOSE: Rod, cone, cone-rod, and macular dystrophies eventually bring about the death of cone photoreceptor cells. The present study explores means of inhibiting apoptosis in addition to inducing a specific apoptotic ... -
Sequencing and analysis of an Irish human genome.
(2010)Background: Recent studies generating complete human sequences from Asian, African and European subgroups have revealed population-specific variation and disease susceptibility loci. Here, choosing a DNA sample from a ... -
Signal perception by the secretion stress-responsive CssRS two-component system in Bacillus subtilis.
(2012)The CssRS two-component system responds to heat and secretion stresses in Bacillus subtilis by controlling expression of HtrA and HtrB chaperone-type proteases and positively autoregulating its own expression. Here we ... -
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins
(2004)Inhibitor of apoptosis proteins (IAPs) can block apoptosis through binding to active caspases and antagonizing their function. IAP function can be neutralized by Smac/Diablo, an IAP-binding protein that is released from ... -
SMURF: genomic mapping of fungal secondary metabolite clusters
(2010)Fungi produce an impressive array of secondary metabolites (SMs) including mycotoxins, antibiotics and pharmaceuticals. The genes responsible for their biosynthesis, export, and transcriptional regulation are often found ... -
Social communication of predator-induced changes in Drosophila behavior and germline physiology
(2015)Behavioral adaptation to environmental threats and subsequent social transmission of adaptive behavior has evolutionary implications. In Drosophila, exposure to parasitoid wasps leads to a sharp decline in oviposition. We ... -
Spatial trends of genetic variation of domestic ruminants in Europe
(2010)The introduction of livestock species in Europe has been followed by various genetic events, which created a complex spatial pattern of genetic differentiation. Spatial principal component (sPCA) analysis and spatial metric ... -
Specification of floral organs in Arabidopsis
(2014)Floral organs are specified by the activities of a small group of transcriptional regulators, the floral organ identity factors. Extensive genetic and molecular analyses have shown that these proteins act as master regulators ... -
Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.
(2009)The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate ... -
Staying alive: defensive strategies in the BCL-2 family playbook.
(2011)Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhibition that exhibit ... -
Structural Calibration of the Rates of Amino Acid Evolution in a Search for Darwin in Drifting Biological Systems.
(Oxford University Press, 2010)In the last two decades, many reports of proteins under positive selection have brought the neutral theory into question. However, the methods used to detect selection have ignored the evolvability of amino acids within ... -
Suite of novel vectors for ectopic insertion of GFP, CFP and IYFP transcriptional fusions in single copy at the amyE andbglSloci in Bacillus subtilis
(Elsevier, 2010)We report the development of a suite of sixintegrative vectors for construction of single copy transcriptional fusions with the gfpmut3, cfp and iyfp reporter genes in B. subtilis. The promoter fusions are constructed using ... -
Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
(2011)For dominantly inherited disorders development of gene therapies, targeting the primary genetic lesion has been impeded by mutational heterogeneity. An example is rhodopsin-linked autosomal dominant retinitis pigmentosa ... -
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
(2009)Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to ... -
A survey of host range genes in poxvirus genomes.
(2013)Poxviruses are widespread pathogens, which display extremely different host ranges. Whereas some poxviruses, including variola virus, display narrow host ranges, others such as cowpox viruses naturally infect a wide range ... -
Survival and innovation: The role of mutational robustness in evolution
(2014)Biological systems are resistant to perturbations caused by the environment and by the intrinsic noise of the system. Robustness to mutations is a particular aspect of robustness in which the phenotype is resistant to ...
