Browsing Genetics (Scholarly Publications) by Title
Now showing items 80-99 of 356
-
The effect of chaperonin buffering on protein evolution.
(2010)Molecular chaperones are highly conserved and ubiquitous proteins that help other proteins in the cell to fold. Pioneering work by Rutherford and Lindquist suggested that the chaperone Hsp90 could buffer (that is, suppress) ... -
Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
(2012)Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted packaging capacity of approximately 5kb. To bypass this limita- tion, ... -
Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho?^'/?^' mouse
(Elsevier, 2015)As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery to the target cells. Recombinant ... -
Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice
(2015)Mouse full-field electroretinograms (ERGs) are dominated by responses of photoreceptors and depolarizing (ON-) bipolar cells, but not much of hyperpolarizing (OFF-) bipolar cells under conventional recording conditions. ... -
Elusive origins of the extra genes in Aspergillus oryzae
(PLoS, 2008)The genome sequence of Aspergillus oryzae revealed unexpectedly that this species has approximately 20% more genes than its congeneric species A. nidulans and A. fumigatus. Where did these extra genes come from? Here, we ... -
Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.
(2009)Summary Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation ... -
Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia
(2017)The juxtacanalicular connective tissue of the trabecular meshwork together with inner wall endothelium of Schlemm’s canal (SC) provide the bulk of resistance to aqueous outflow from the anterior chamber. Endothelial cells ... -
Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1
(2017)Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors ... -
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
(2014)Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to ... -
Essentiality is a strong determinant of protein rates of evolution during mutation accumulation experiments in Escherichia coli
(2016)The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. One of the main predictions of this theory is that essential proteins should evolve ... -
Estimation of synteny conservation and genome compaction between pufferfish (Fugu) and human.
(2000)BACKGROUND: Knowledge of the amount of gene order and synteny conservation between two species gives insights to the extent and mechanisms of divergence. The vertebrate Fugu rubripes (pufferfish) has a small genome with ... -
Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi
(BioMed Central, 2008)Background Filamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis. Genes from the same pathway are often clustered and co-expressed in particular ... -
Evidence for sponges as sister to all other animals from partitioned phylogenomics with mixture models and recoding
(2021)Resolving the relationships between the major lineages in the animal tree of life is necessary to understand the origin and evolution of key animal traits. Sponges, characterized by their simple body plan, were traditionally ... -
Evidence from comparative genomics for a complete sexual cycle in the "asexual" pathogenic yeast Candida glabrata
(BioMed Central, 2003)BACKGROUND: Candida glabrata is a pathogenic yeast of increasing medical concern. It has been regarded as asexual since it was first described in 1917, yet phylogenetic analyses have revealed that it is more closely related ... -
Evidence from Drosophila Supports Higher Duplicability of Faster Evolving Genes
(2022)The faster rate of evolution of duplicated genes relative to singletons has been well documented in multiple lineages. This observation has generally been attributed to a presumed release from constraint following creation ... -
Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus
(2009)BACKGROUND: The comparative analysis of genome sequences emerging for several avian species with the fully sequenced chicken genome enables the genome-wide investigation of selective processes in functionally important ... -
Evolution of Vertebrate Tissues Driven by Differential Modes of Gene Duplication.
(2012)In this study, we investigated the evolution of vertebrate tissues by examining the potential association among gene expression, duplication, and base substitution patterns. In particular, we compared whole-genome duplication ... -
Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents
(National Academy of Sciences, 2011)We investigate yeast sex chromosome evolution by comparing genome sequences from 16 species in the family Saccharomycetaceae, including data from genera Tetrapisispora, Kazachstania, Naumovozyma, and Torulaspora. We show ... -
Evolutionary Origins of the Fumonisin Secondary Metabolite Gene Cluster in Fusarium verticillioides and Aspergillus niger
(SAGE-Hindawi, 2011)The secondary metabolite gene clusters of euascomycete fungi are among the largest known clusters of functionally related genes in eukaryotes. Most of these clusters are species specific or genus specific, and little is ... -
Evolutionary rate and duplicability in the Arabidopsis thaliana protein-protein interaction network
(2012)Genes show a bewildering variation in their patterns of molecular ev olution, as a result of the action of different levels and types of selective forces. The factors underlying this variation are, however, s till poorly ...