Browsing Genetics (Scholarly Publications) by Title
Now showing items 326-345 of 356
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Tight Junctions of the Neurovascular Unit
(2021)The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the ... -
Tight junctions of the outer blood retina barrier
(2020)The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is the presence of the tight junction ... -
To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps
(Springer Nature, 2019)Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics andphysiological functions of NETs have been uncovered. Nowadays, thefield continues to expand and novel ... -
A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection.
(2014)Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. ... -
Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation
(2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
Transplantation of syngeneic schwann cells to the retina of the rhodopsin knockout (Rho-/-) mouse
(The Association for Research in Vision and Ophthalmology, Inc., 2003)PURPOSE: To determine whether subretinal Schwann cell transplantation can prolong the survival of photoreceptors in the rhodopsin knockout (rho(-/-)) mouse. METHODS: Schwann cells were prepared from postnatal day (PN) 5 ... -
Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis.
(Nature, 2011)P53 inactivation is often observed in Burkitt's lymphoma (BL) cells due to mutations in the p53 gene or overexpression of its negative regulator, murine double minute-2 (MDM2). This event is now considered an essential ... -
Two forgotten poems by John Tyndall (1841)
(2013)Two poems published by John Tyndall (under the pseudonym "W.S.") in 1841 in his local newspaper The Carlow Sentinel are presented and their historical context revealed. The poems are of a political nature and intended to ... -
The uneasy correspondence between T. H. Huxley and E. P. Wright on fossil vertebrates found in Jarrow, Co. Kilkenny (1865-67)
(2011)The collection of Carboniferous fish and amphibian fossils found in Jarrow in 1864 has been the object of several studies, and has resided successively in at least three Irish museums. This paper draws from the Huxley ... -
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.
(2015)We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus ... -
Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants
(2022)Usher syndrome (USH) is an autosomal recessively inherited disease characterized by sensorineural hearing loss (SNHL) and retinitis pigmentosa (RP) with or without vestibular dysfunction. It is highly heterogeneous both ... -
Using single molecule Molecular Inversion Probes as a cost-effective, high-throughput sequencing approach to target all genes and loci associated with macular diseases
(2022)Macular degenerations (MDs) are a subgroup of retinal disorders characterized by central vision loss. Knowledge is still lacking on the extent of genetic and nongenetic factors influencing inherited MD (iMD) and age-related ... -
Validation in mesenchymal progenitor cells of a mutation-independent ex vivo approach to gene therapy for osteogenesis imperfecta
(Oxford University Press, 2002)Over 100 dominant-negative mutations within the COL1A1 gene have been identified in osteogenesis imperfecta (OI). In terms of human therapeutics, targeting each of these mutations independently is unlikely to be feasible. ... -
Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data
(2019)Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in ... -
Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle
(2014)Open Access Research Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle Ian W Richardson12, Dan G Bradley1, Isabella M Higgins3, Simon J More3, Jennifer McClure4 and Donagh ... -
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
(2015)PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional repression and developmental gene regulation. Individual PCGF proteins define discrete Polycomb Repressor Complex 1 (PRC1) ... -
Versatile Dual Reporter Gene Systems for Investigating Stop Codon Readthrough in Plants
(2009)Background Translation is most often terminated when a ribosome encounters the first in-frame stop codon (UAA, UAG or UGA) in an mRNA. However, many viruses (and some cellular mRNAs) contain ?stop? codons that cause a ...