Browsing Genetics (Scholarly Publications) by Title
Now showing items 163-182 of 356
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IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
(2019)Background: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health ... -
In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae
(2007)Background Heat-shock proteins are specialized molecules performing different and essential roles in the cell including protein degradation, folding and trafficking. GroEL is a 60 Kda heat-shock protein ubiquitous in ... -
Increased glycolytic flux as an outcome of whole-genome duplication in yeast
(BioMed Central, 2007)After whole-genome duplication (WGD), deletions return most loci to single copy. However, duplicate loci may survive through selection for increased dosage. Here, we show how the WGD increased copy number of some glycolytic ... -
An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.
(2013)Bacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered ... -
Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram.
(Association for Research in Vision and Ophthalmology, 2008)PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake ... -
Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production.
(2013)Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger ... -
Insufficient Evidence for "Autism-Specific" Genes
(2020)Despite evidence that deleterious variants in the same genes are implicated across multiple neurodevelopmental and neuropsychiatric disorders, there has been considerable interest in identifying genes that, when mutated, ... -
Interacting gene clusters and the evolution of the vertebrate immune system.
(2008)Unraveling the "code" of genome structure is an important goal of genomics research. Colocalization of genes in eukaryotic genomes may facilitate preservation of favorable allele combinations between epistasic loci or ... -
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation
(2004)Caspases coordinate the internal demolition of the cell that is seen during apoptosis. Proteolytic processing of caspases is observed during apoptosis, and this correlates with conversion of inactive caspase proenzymes ... -
Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
(2013)Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase ... -
ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
(eLife Sciences Publications, 2018)The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves ... -
John Tyndall: Peaks and troughs.
(2013-07-01)The scientist and natural philosopher John Tyndall was known to the public through his lectures and newspaper debates. But, say Miguel DeArce and Norman MacMillan, one of Tyndall?s most famous public speeches, his ... -
A letter from William B. Brownrigg to Thomas H. Huxley, dated 29 November 1865, authorising him to describe his fossil vertebrates from Jarrow Colliery, Co. Kilkenny and giving details of his find
(2011)William Bookey Brownrigg, who discovered the Upper Carboniferous (Pennsylvanian) vertebrate fossils at Jarrow Colliery, Co. Kilkenny in 1864, published a short paper on the material. Shortly afterwards E.P. Wright, a ... -
LineUp: Statistical Detection of Chromosomal Homology with Application to Plant Comparative Genomics
(2003)The identification of homologous regions between chromosomes forms the basis for studies of genome organization, comparative genomics, and evolutionary genomics. Identification of these regions can be based on either synteny ... -
Localized hypermutation and associated gene losses in legume chloroplast genomes
(2010)Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related ... -
Macrosynteny analysis shows the absence of ancient whole-genome duplication in lepidopteran insects
(2019)Whole-genome duplication (WGD) is considered a key evolutionary event for genetic innovation and has occurred in diverse eukaryotic lineages (1). In PNAS, Li et al. (2) report multiple WGD events in hexapods, which is ... -
Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome.
(2012)How and why female somatic X-chromosome inactivation (XCI) evolved in mammals remains poorly understood. Ohno proposed a two-step process where XCI is a dosage-compensation mechaQ: 7 nism that evolved to equalize ... -
MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI
(2013)BACKGROUND AND PURPOSE: The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL ...
