Browsing Genetics (Scholarly Publications) by Title
Now showing items 152-171 of 356
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Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
(2009)Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable ... -
A Highly Unstable Transcript Makes CwlO D, L-Endopeptidase Expression Responsive to Growth Conditions in Bacillus subtilis
(2014)The Bacillus subtilis cell wall is a dynamic structure, composed of peptidoglycan and teichoic acid, that is continually remodeled during growth. Remodeling is effected by the combined activities of penicillin binding ... -
The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.
(2014)Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly under- stood. The Drosophila Roundabout (Robo) receptors regulate ... -
How Much Is That in Dog Years? The Advent of Canine Population Genomics
(2014)ABSTRACT The authors comment on two studies that analyzed multiple genomes of dogs and wolves. The studies reached different conclusions about the date and population effects, a disparity attributed to reliance on molecular ... -
How to prepare and deliver a great talk
(2019)Giving a talk can be daunting, particularly for scientists at the very early stages of their careers. Standing in front of an audience and speaking for 20–30 minutes do is never easy, and even those who do it for a ... -
Identification and Structural Characterization of Interneurons of the Drosophila Brain by Monoclonal Antibodies of the Wurzburg Hybridoma Library
(2013)Several novel synaptic proteins have been identified by monoclonal antibodies (mAbs) of the Würzburg hybridoma library generated against homogenized Drosophila brains, e.g. cysteine string protein, synapse-associated protein ... -
Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach
(2008)Background: Poxviruses are important pathogens of humans, livestock and wild animals. These large dsDNA viruses have a set of core orthologs whose gene order is extremely well conserved throughout poxvirus genera. They ... -
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
(2019)Background: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health ... -
In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae
(2007)Background Heat-shock proteins are specialized molecules performing different and essential roles in the cell including protein degradation, folding and trafficking. GroEL is a 60 Kda heat-shock protein ubiquitous in ... -
Increased glycolytic flux as an outcome of whole-genome duplication in yeast
(BioMed Central, 2007)After whole-genome duplication (WGD), deletions return most loci to single copy. However, duplicate loci may survive through selection for increased dosage. Here, we show how the WGD increased copy number of some glycolytic ... -
An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.
(2013)Bacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered ... -
Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram.
(Association for Research in Vision and Ophthalmology, 2008)PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake ... -
Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production.
(2013)Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger ... -
Insufficient Evidence for "Autism-Specific" Genes
(2020)Despite evidence that deleterious variants in the same genes are implicated across multiple neurodevelopmental and neuropsychiatric disorders, there has been considerable interest in identifying genes that, when mutated, ... -
Interacting gene clusters and the evolution of the vertebrate immune system.
(2008)Unraveling the "code" of genome structure is an important goal of genomics research. Colocalization of genes in eukaryotic genomes may facilitate preservation of favorable allele combinations between epistasic loci or ... -
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation
(2004)Caspases coordinate the internal demolition of the cell that is seen during apoptosis. Proteolytic processing of caspases is observed during apoptosis, and this correlates with conversion of inactive caspase proenzymes ...
