Browsing School of Biochemistry & Immunology by Date of Publication
Now showing items 1-20 of 1013
-
Cellular response to alpha-gliadin in untreated coeliac disease.
(1982)An improved technique for the detection of alpha-gliadin sensitised mononuclear cells in the peripheral blood of untreated coeliac patients is described. This method is a modification of the direct LMIF assay, and involves ... -
Alpha gliadin antibody levels: a serological test for coeliac disease.
(1983)The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen ... -
Increased concanavalin A induced suppression in treated and untreated coeliac disease.
(1984)The generation of suppression by concanavalin A in peripheral blood mononuclear cells in treated and untreated coeliac subjects using an in vitro assay was found to be significantly increased when compared with controls. ... -
T cell subpopulations in B cell chronic lymphocytic leukemias
(British Society for Immunology, 1984) -
Kinetics of the main phase transition of hydrated lecithin monitored by real-time X-ray diffraction.
(Elsevier, 1984)A method is described for observing and recording in real-time x-ray diffraction from an unoriented hydrated membrane lipid, dipalmitoylphosphatidylcholine (DPPC), through its thermotropic gel/liquid crystal phase transition. ... -
Gliadin antibody detection in gluten enteropathy.
(1986)Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be ... -
Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma.
(1986)Features that might distinguish uncomplicated coeliac disease from enteropathy associated T cell lymphoma were investigated. Of 76 patients with coeliac disease, 71 (93%) had raised levels of alpha gliadin antibody and all ... -
Humoral response to alpha gliadin as serological screening test for coeliac disease.
(1987)The diagnostic value of measuring alpha gliadin antibodies in children with suspected coeliac disease has been evaluated prospectively. Jejunal biopsy and alpha gliadin antibody measurements were performed in 77 consecutive ... -
Histological changes associated with wheat protein antibodies in the absence of villous atrophy.
(1987)A retrospective study was conducted to assess the association of alpha-gliadin antibodies with intraepithelial lymphocyte counts. Twelve subjects with apparently normal small intestinal histology and raised alpha-gliadin ... -
Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel.
(1987)Immunohistological analysis of the cellular composition of the small intestinal mucosa in a group of untreated and treated coeliac patients and non-coeliac control subjects was performed using monoclonal antibodies and an ... -
Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect
(British Pharmacological Society, 1987)Feverfew has been used since antiquity to treat inflammatory conditions. Extracts of the herb were found to inhibit mitogen-induced tritiated thymidine ([3H]-TdR) uptake by human peripheral blood mononuclear cells (PBMC), ... -
A temperature gradient method for lipid phase diagram construction using time-resolved x-ray diffraction.
(1987)A method that enables temperature-composition phase diagram construction at unprecedented rates is described and evaluated. The method involves establishing a known temperature gradient along the length of a metal rod. ... -
Two new and rapid approaches for studying the phase properties of cosmetic lipids and oils
(Society of Cosmetic Chemists, 1988)Lipids and oils, integral components of cosmetic products, exist in a number of intermediate physical states, or mesomorphic phases, between the crystalline solid and isotropic liquid. The stability of these phases depends ... -
Lipid-sugar interaction: Relevance to anhydrous biology
(American Society of Plant Biologists, 1988)The ability of seeds and other anhydrous plant forms to survive the withdrawal of water must involve a mechanism for protecting the integrity of cellular membranes. Evidence from animal systems implicates sugars as protective ... -
Altered gastrointestinal immune response in sarcoidosis.
(1988)Because of the possible clinical association between coeliac disease and sarcoidosis, the incidence of humoral sensitivity to dietary proteins was examined in patients with sarcoidosis. Raised concentrations of circulating ... -
Inhibitory effects of monoclonal antibodies to a synthetic peptide of influenza haemagglutinin on the processing and presentation of viral antigens to class II-restricted T cell clones
(British Society for Immunology, 1988)Monoclonal antibodies (mAb) prepared against a synthetic peptide of influenza virus haemagglutinin (HA), containing a known T-cell determinant, were used to examine the mechanism of antigen-induced activation of HA-specific ... -
A lyotrope gradient method for liquid crystal temperature-composition-mesomorph diagram construction using time-resolved x-ray diffraction.
(1989)A new method for rapidly constructing isobaric temperature-composition-mesomorph (T-C) diagrams is described. The method involves establishing a lyotrope concentration gradient in a liquid crystal lengthwise in an x-ray ... -
Diversity of the class II (I-Ak/I-Ek) restricted T-cell repertoire for influenza haemagglutinin and antigenic drift: six non-overlapping epitopes on the HA1 sub-unit are defined by synthetic peptides
(The Rockefeller University Press, 1989)H-2k-restricted T cell clones derived from CBA mice infected with X31 (H3N2) influenza virus, were shown to recognize distinct, nonoverlapping sequences within the HA1 subunit of the viral hemagglutinin (HA) using synthetic ... -
Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
(The American Society for Biochemistry and Molecular Biology, 1990)The post-receptor events which follow the binding of interleukin 1 (IL1) to cells are unclear. The present studies provide evidence for the activation of a guanine nucleotide binding protein (G protein) by IL1 in the ... -
Kinetics of the premelting (L beta'-P beta') and main transition (P beta'-L alpha) in hydrated dipalmitoylphosphatidylcholine. A time-resolved x-ray diffraction study using microwave-induced temperature-jumps.
(1990)The dynamics and mechanism of the premelting (L beta'-P beta') and main transitions (P beta'-L alpha) in fully hydrated dipalmitoylphosphatidylcholine were examined by low-angle time-resolved x-ray diffraction (TRXRD) using ...