Browsing Genetics (Theses and Dissertations) by Title
Now showing items 149-168 of 191
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Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The H-NS protein represses the transcription of hundreds of genes in Gram-negative bacteria. De-repression is achieved by a multitude of mechanisms, many of which involve binding of a protein to DNA at the repressed promoter ... -
Retrieval of DNA from ancient material and the demography of the extinct aurochs
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Ancient DNA has revolutionised our understanding of animal genomics by providing direct evidence of the demography of ancient wild populations and unravelling the complex domestication process with time-stamped precision. ... -
RNP granules-dependent translational regulation in habituation and development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Habituation is defined as a reduced behavioral response to a stimulus after repeated or continuous exposure. Long-term habituation (LTH) is a long-lasting form of non-associative memory which is dependent on de novo protein ... -
Role of CED-9/cl-2 family proteins in mitochondrial fission and fusion dynamics
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Programmed cell death in the nematode C. elegans is the equivalent process to human apoptosis. Studying this process in the model organism has led to a great amount of knowledge about the details of pathway steps and ... -
The role of death receptors in ER stress and Inflamation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Cell death induced in response to ER stress, particularly in response to classical ER stress-inducing agents thapsigargin, brefeldin A and tunicamycin, has been shown to be dependent on the ER stress-dependent upregulation ... -
Specification of floral reproductive organs : the role of AGAMOUS
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)Homeosis is referred to as the transformation of an organ's identity toward the identity of another organ. This term was coined in 1894 and soon thereafter; these organ transformations were attributed to the variation in ... -
Staphylococcus lugdunensis : Genome sequence, genetic systems, virulence and an amplifiable isd locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus lugdunensis is a coagulase negative staphylococcus (CoNS). Infections caused by CoNS are normally less severe than infections caused by S. aureus. However, S. lugdunensis is associated with a series of severe ... -
Stasis and flux: A genomic study of 20,000 years of European prehistory.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis presents whole-genome shotgun sequencing data from 79 ancient humans, spanning 20,000 years of European prehistory, from the Upper Palaeolithic to the Iron Age. The aim of this research was to fill in missing ... -
Sterile inflammation and age-related macular degeneration
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, estimated to affect 196 million people worldwide by 2020 (Wong et ai, 2014). AMD primarily affects ... -
Studies on Irish families with autosomal dominant retinitis pigmentosa, congenital stationary night blindness and on mouse models of inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)This thesis describes over 17 years of research into the molecular genetics of inherited retinopathies including Retinitis Pigmentosa (RP), the most prevalent form of inherited blindness world-wide, and Congenital Stationary ... -
Surface proteins and restriction-modification systems of bovine mastitis strains of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus aureus is frequently associated with bovine mastitis, one of the most economically important diseases in the dairy industry. The bovine S. aureus strain RF122 represents a geographically widespread clone ... -
Sustained expression of fis, the gene coding for the Fis nucleoid-associated protein, during the stationary phase of growth in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)The Factor for Inversion Stimulation (Fis) is a global regulator of virulence genes in Salmonella enterica serovar Typhimurium. Previously, the Fis protein was throught to be expressed only during the early exponential ... -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ... -
Testing the hypothesis of genome duplications in vertebrates
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The hypothesis that the human genome has undergone at least two rounds of genome duplication has become widely accepted, but has never been rigorously tested. In this study, several map-based inter- and intra-species ... -
The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ... -
The development of gene therapy techniques and animal models for Retinitis Pigmentosa and towards the identification of a novel RP-causing gene in a family of Irish origin
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)The work presented in this thesis pertains to several different stages in the preclinical development of therapeutics for inherited retinal disease. Chapter two addresses the difficult challenge of delivery of therapeutics ... -
The double-edged complexity of molecular sequence evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Traditionally, phylogenetic studies based on sequence data assume simple models of evolution. This is due to computational and time constraints and to our incomplete understanding of the actual complexity of the evolutionary ... -
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The work presented in this thesis describes a comprehensive analysis of the YycFG two-com ponent system (TCS) in Bacillus subtilis. TCSs are widespread mechanisms used by bacteria to sense and respond to the prevailing ... -
The evolution of molecular chaperones and their clients
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Molecular chaperones are ancient and ubiquitous proteins that help other proteins in the cell to fold. In this thesis, we investigate the evolution of assisted protein folding from two perspectives: the evolution of the ... -
The genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ...