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Now showing items 116-135 of 191

  • Mechanisms of action and vulnerabilities associated with the oncogene EZH2 in germinal centre B-cell non-Hodgkin lymphoma 

    Nolan, James Michael (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)
    Polycomb group (PcG) proteins are highly conserved chromatin regulators that play a critical role as transcriptional repressors in mediating and maintaining cellular identity. PcG proteins assemble into large, distinct, ...
  • MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis 

    Vegh, Peter (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ...
  • Mitochondrial genes associated with cytoplasmic male sterility in Lolium perenne 

    McDermott, Paul (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
    This study involved molecular investigations of cytoplasmic male sterility (CMS) in perennial ryegrass (Lolium perenne L). The CMS line originated as an interspecific hybrid between L. perenne (male parent) and Festuca ...
  • Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies 

    O'Dwyer, Gareth (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ...
  • Modulation of the blood-brain barrier for therapeutic benefit 

    Hanrahan, Finnian (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 ...
  • Molecular and quantative analyses of genetic variation in farmed Atlantic salmon 

    Norris, A. T. (Trinity College (Dublin, Ireland). Department of Genetics, 2003)
    Genetic diversity between three farmed and four wild populations and within six 6 year classes of one farmed population of Atlantic salmon were analysed using 15 microsatellite markers. High levels of polymorphism were ...
  • Molecular genetic investigations of the diversity and origins of Old and New World cattle population 

    Magee, David Andrew (Trinity College (Dublin, Ireland). Department of Genetics, 2003)
    One hundred and forty-nine Bos indicus mitochondrial DNA (mtDNA) control region sequences sampled from the Indian subcontinent, the Near East and East Asia were assessed in order to investigate the domestic origins and ...
  • The Multilayered Prehistory of Wild Aurochs and Domestic Cattle 

    Bradley, Daniel; European Research Council (ERC) (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    This thesis explores 122 ancient genomes of domestic cattle and wild aurochs to investigate past population events such as domestication and admixture. Population genomics of ancient taurine domestics from the ancient Near ...
  • A new family of vertebrate-specific Polycombs encoded by the Lcor/Lcorl genes balance PRC2 subtype activities 

    Bracken, Adrian; BREAST-Predict; Irish Cancer Society (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    The Polycomb Repressive Complex 2 (PRC2) is composed of the core subunits SUZ12, EED, RBBP4/7 and EZH1/2, which together are responsible for all di- and tri- methylation of lysine 27 on Histone H3 (H3K27me2/3). In addition, ...
  • Next generation sequencing of ancient DNA 

    Teasdale, Matthew David (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
    The application of next generation sequencing (NGS) technologies into the field of ancient DNA has seen a paradime shift in the level of analysis that can be completed using archaeological samples. However, to fully access ...
  • A novel gene-based therapy for galaucoma:from discovery to preclinical development 

    O'CALLAGHAN, JEFFREY (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    Introduction: Glaucoma is a multifactorial condition that will often result in complete bilateral blindness if untreated. Elevated intraocular pressure (IOP) is both a major risk factor and indicator of disease. IOP is ...
  • Novel therapeutic approaches for open-angle glaucoma 

    Kelly, Ruth (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)
    Glaucoma is the leading cause of blindness worldwide after cataracts and it is estimated that the global prevalence of glaucoma will increase to 111.8 million by 2040 (1, 2). Primary open-angle glaucoma (POAG) is characterized ...
  • Novel therapeutic strategies for autosomal dominant retinitis pigmentosa 

    O'Neill, Brian G. D. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)
    A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ...
  • Olfactory-avoidance habituation in Drosophila melanogaster 

    Lee, John (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Habituation is a form of sensory filtering in response to prolonged or repeated stimuli in the environment [Harris, 1943; Thompson and Spencer, 1966; Christoffersen, 1997; Rankin et al., 2009], It provides biological ...
  • On the development of animal models for degenerative retinal disease 

    McNally, Niamh (Trinity College (Dublin, Ireland). Department of Genetics, 2000)
    Retinitis pigmentosa (RP) is one of the leading causes of inherited blindness within the working population of many developed countries. There is presently no cure for this disorder. The projects outlined in this thesis ...
  • On the development of molecular approaches to therapy for retinitis pigmentosa 

    Nguyen, Anh Thi Hong (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    Endothelial cells lining the microvasculature of the retina have highly evolved “tight junctions” reducing the space between adjacent cells to form a selective and highly regulatable barrier called the inner blood-retina ...
  • On the genetics of retinal function and disease 

    Reynolds, Alison Louise (Trinity College (Dublin, Ireland). Department of Genetics, 2006)
    There are many recorded examples in which genetic background has been shown to radically influence retinal phenotypes in inbred mouse strains. For example, the manifestations of a targeted knockout of the p53 gene are much ...
  • On the molecular genetics of bipolar affective disorder 

    Lambert, David Brendan James (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    This thesis describes genome-wide gene mapping analyses as applied to bipolar affective disorder (BPAD). This condition is a severe recurrent psychiatric disorder, with a substantial familial component and an estimated ...
  • On the molecular genetics of bipolar disorder 

    Kealey, Carmel (Trinity College (Dublin, Ireland). Department of Genetics, 2003)
    A modified genome scan, concentrating primarily on gene rich regions of the genome was employed by this group to search for regions harboring susceptibility loci for bipolar disorder in a panel of 48 Irish sib-pair families ...
  • On the molecular genetics of hereditary degenerative retinopathies 

    Aherne, Aileen Mary (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the retina. The main focus of study concentrates on the molecular genetics and disease mechanisms in ...