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  • Cartilage extraceullular matrix-derived scaffolds for joint regeneration 

    Vazão de Almeida, Henrique Martiniano (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)
    The goal of this thesis was to address key limitations associated with autologous chondrocyte implantation (ACI) for articular cartilage regeneration, specifically the need for two hospital stays, cell culture and high ...
  • Case study of the Home Energy Saving Scheme : a multidisciplinary approach 

    Byrne, Amiee Jennifer (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    The EU has set itself the objective of achieving 20% primary energy savings by 2020. Because of the relatively recent move towards sustainability, there is a limited understanding of how effective related policies and ...
  • Characterisation and modelling of electro-pneumatic production systems 

    Harris, Paul (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    Compressed air is a widely employed energy source in modern manufacturing, accounting for a large percentage of plant electrical energy usage. However, the energy efficiency of such systems can be particularly low. Accurate ...
  • Characterisation and Reduction of Aircraft Landing Gear Noise 

    NERI, ELEONORA (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2017)
    Aircraft noise has become an important concern in aviation design as it has a negative impact on the health of people living in the vicinity of airports. The total noise of an aircraft is generated by the engines and by ...
  • Characterisation of an integrated telemetric temperature sensor for CFRP milling applications 

    Kerrigan, Kevin (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)
    The concept of a sensor designed to measure the behaviour of a machining process is a fundamental part of process monitoring and control. The perception of such a sensor is often underestimated when novel applications are ...
  • Characterisation of the performance of single point diamond dressers in abrasive processes 

    Murphy, Stuart (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    This thesis presents in-depth investigation and analysis of the dressing of conventional grinding wheels. Grinding is used in the manufacturing industry to achieve a high surface finish which is an important constituent ...
  • Characterization of the Erosion of Soft Tissue by Surgical Mesh In Vitro 

    SCHMIDT, AMANDA (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)
    Surgical mesh implants have been extensively used in hernia treatment and pelvic organ procedures, such as organ prolapse and stress urinary incontinence. Since the onset of the use of such implants, major complications ...
  • Composite scaffold development and bioreactor culture for bone tissue engineering 

    Plunkett, Niamh (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)
    Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into ...
  • Composition and mechanical properties of osteoarthritic subchondral trabecular tibial bone 

    Gleeson, John Patrick (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)
    Osteoarthritis is a disease that has been characterised historically by the focal destruction of cartilaginous tissue and hence, is defined as such. However, recent investigations have brought this pathology into contention. ...
  • Computational and experimental investigation of bone cell response to mechanical stimuli 

    McGarry, James Gerard (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)
    The importance of mechanical loading in maintaining bone quality is well illustrated by the drastic effects of its absence in, for example, microgravity, cast immobilisation or paraplegia. The mechanisms underlying adaptation ...
  • Computational investigation into the mechanoregulation of osteoporosis 

    Mulvihill, Bríanne Mary Claire (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)
    Trabecular bone remodelling involves the continual resorption and formation of bone along the surface of a strut. Experimental studies have shown that mechanical stimuli, such as strain and damage, initiate and regulate ...
  • Computational investigations of mesenchymal stem cell ageing in mechanobiological simulations of tissue differentiation 

    Xue, Feng (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    Musculoskeletal health is a major determinant of the quality of life for the increasing aged population groups in our society. Improved healthcare is essential to ensure successful ageing and enhanced musculoskeletal health ...
  • Computational investigations of variability in mechanobiological simulations of tissue differentiation 

    Khayyeri, Hanifeh (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    Theories of mechanoregulation have been integrated in computational models of mechanobiological experiments to test hypotheses of mechanobiology. It is believed that computational models need to be improved by considering ...
  • Computational modelling of bone regeneration using a three-dimensional lattice approach 

    Byrne, Damien Paul (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)
    Mechano-regulatory theories are indispensable for developing and understanding how mechanical forces modulate morphological and structural fitness of skeletal tissues. These theories have been incorporated into computational ...
  • Computational simulation of the mechanobiological response of arterial tissue 

    Boyle, Colin James (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    Ischaemic heart disease, causing restriction of arterial blood flow to the heart tissue, can be treated with mechanical revascularisation treatments such as balloon angioplasty and stent implantation. One remaining limitation ...
  • Cooling by high speed air jet in orthogonal machining operations 

    Bareggi, Andrea (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    Changing environmental awareness has led manufacturing industry to give critical consideration to the use of conventional coolants and traditional cooling techniques in machining processes. Current research shows that ...
  • Deciphering the Molecular Mechanisms of Stem Cell Mechanotransduction: A New Avenue for the Development of Therapeutics for Osteoporosis 

    CORRIGAN, MICHELE (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)
    Osteoporosis is characterised by reduced bone density and weakened bone architecture leading to high fracture risk. The changes in bone result from an imbalance in the bone remodelling cycle whereby the rate of resorption ...
  • Design and development of a pre-clinical test for cemented femoral hip replacements 

    Maher, Suzanne Adele (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2000)
    Current state of the art testing methods do not allow implant performance to be assessed relative to known failure modes, prior to clinical use. Even clinically, it can take up to 5 years before implant performance can be ...
  • Design and optimisation of focused infrared heating devices 

    JENKINS, RICHARD JAMES (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)
  • Design, manufacture, modelling and testing of surface acoustic wave strain sensors 

    Mc Cormack, Brian (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)
    There is an increasing demand for multi-sensor strain measurement systems, particularly those which incorporate wireless sensors. A possible application of such a system is the Real-Time Weigh-In-Motion (RTWIM) of heavy ...