Browsing Mechanical & Manufacturing Eng (Theses and Dissertations) by Title
Now showing items 24-43 of 217
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An improved framework for the inverse analysis of skeletal muscle tissue in-vivo
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)This thesis focusses on the development of an experimental and computational framework for the non-invasive analysis of the passive mechanical properties of living human skeletal muscle tissue. This is relevant to many ... -
An investigation into the causes of higher rates of restenosis in peripheral arteries compared with coronary arteries following stenting
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2010)The use of stenting in peripheral arteries has been limited by rates of in-stent restenosis and stent fracture considerably higher than seen in coronary arteries. Traditional balloon expandable stainless steel stents were ... -
An investigation into the influence of cardiovascular stent design on the development of restenosis using the finite element method
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)Finite element models, which can determine the degree of vascular injury caused to a vessel by a stent and hence ascertain the propensity of that stent design to cause in¬stent restenosis, would be a valuable tool for both ... -
An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Mesenchymal stem cells (MSCs) are multipotent cells which can differentiate down multiple lineages and potentially generate tissues such as cartilage, bone or adipose tissue. It is becoming increasingly clear that mechanical ... -
An investigation of joint tissue derived stem cells for articular cartilage tissue engineering
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)Tissue engineering has emerged as a promising approach to repair damaged articular cartilage. The associated drawbacks with the isolation and expansion of chondrocytes from autologous tissue have prompted significant ... -
An investigation of structure-function relations in articular cartilage during skeletal maturation
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The over-riding objective of this thesis was to build upon our current understanding of the evolving nature of articular cartilage mechanics by elucidating how changes to structure and composition of the tissue during ... -
An optimized surface topography for calcium phosphate bone tissue engineering scaffolds
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)Improved scaffold/host integration and avoiding core necrosis are important and active goals in tissue engineering. Alternatives to bone tissue grafting that are highly bioactive and inexpensive to manufacture are clinical ... -
Analysing the effects of 3D printing defects and surface roughness on the properties of acoustic materials
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)The principal aim of the research reported in this thesis was to investigate the influence of additive manufacturing on the acoustic performance of 3D printed periodic materials. First, a benchmark material design was ... -
Analysis of noise source mechanisms for a subsonic jet
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)Despite advances in engine design, from high bypass to co-axial or lobe shaped nozzles, the problem of jet noise reduction continues to require ongoing research in order to comply with the criteria inherent in environmental ... -
Analysis of the elastic and inelastic behaviour of healthy and diseased arterial tissue
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Mechanical factors play a key role in determining the success of clinical procedures such as balloon angioplasty and stenting that aim to increase lumen size in atherosclerotic lesions. Finite element modelling is commonly ... -
Application of the Theory of Critical Distances to As-Built Selective Laser Melted Ti-6Al-4V
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2024)Metal additive manufacturing (AM) techniques such as selective laser melting (SLM) have become an increasingly present feature of new and novel manufacturing methods in recent years. This is owed to further technological ... -
Applying thermal post-processing techniques to engineer the microstructure and mechanical performanceof selective-laser-melted Ti-6Al-4V ELI
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)As an additive manufacturing technology, selective laser melting (SLM) affords the creation of customisable parts at high resolutions to within the micron range. Among the materials being processed by SLM systems, the ... -
Aspects of the fatigue behaviour of acrylic bone cement
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2002)Polymethylmethacrylate bone cement is used to fixate many orthopaedic implants. However, it is a brittle material, prone to damage accumulation leading to cement cracking and prosthesis loosening. The damage accumulation ... -
BIOFABRICATION STRATEGIES TO GUIDE THE SELF-ORGANISATION OF BIOMIMETIC CARTILAGE AND OSTEOCHONDRAL TISSUES
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure, composition and functional properties of the target tissue. This has ... -
A biomechanical analysis of cyclist collisions in Ireland
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)As both a mode of transport and recreational activity, cycling has well-known health, environmental, and economic benefits. For these reasons, it has been encouraged in many countries, including the Republic of Ireland. ... -
A Biomechanical Assessment of Direct and Inertial Head Loading in Rugby Union
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)Rugby union is a territorial, dynamic and high-impact collision sport. Unfortunately, due to its physical and high impact nature, the incidence of concussion is high. There is mounting evidence that repeatedly sustaining ... -
Biomechanical origins of osteoporosis
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)The contention of this thesis is that a pathological change in bone tissue material properties during osteoporosis ahers the mechanical stimuli to bone remodelling cells and drives them to adapt the trabecular architecture ... -
Biomechanics of Repair in Invertebrates
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate. Though the process of repair has been studied in mammals, very little ... -
Biophysical Regulation of Stem Cell Osteogenic Lineage Commitment: A Role for the Cytoskeleton
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is a debilitating disease characterised by weakened bone architecture due to increased resorption activity of osteoclasts and diminished bone deposition by mesenchymal stem cell (MSC) derived osteoblasts. ... -
Boundary element methods for the prediction of aircraft noise shielding in flight
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)Aircraft noise emissions may be significantly reduced by positioning the aeroengines above the wings or fuselage so as to utilize the shielding effect of the airframe. Computational tools are likely to play a key role in ...