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Now showing items 114-133 of 149

  • Responses of bone cells to microinjury 

    Mulcahy, Lauren Elizabeth (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    Microdamage in bone has been implicated as a principal stimulator of bone remodeling through the release of numerous biochemical factors. Such factors initiate the bone resorbing and bone forming potential of the constitutive ...
  • Simulation of bone fracture and cutting using the theory of critical distances 

    Kasiri Ghahi, Saeid (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)
    This work was concerned with the prediction of bone fracture in situations where fracture was initiated in areas of stress concentration. Two conditions were studied: (i) fracture in bones and bone samples weakened by the ...
  • Simulation of tissue differentation during fracture healing 

    Lacroix, Damien (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2001)
    Fracture healing is a complex biological process during which, repair of the damaged tissues occurs so efficiently that the initial strength and anatomy of the bone are restored. Mechanical loading is believed to greatly ...
  • Spatial presentation of tissue specific extracellular matrix components and growth factors on porous electrospun fibre scaffolds for bone-ligament interface tissue engineering 

    OLVERA, DINORATH PAMELA (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)
    In many clinical situations ligament or tendon replacements are required, such as for the surgical replacement of a torn anterior cruciate ligament (ACL). The current ‘gold standard’ treatment is resection of the torn ...
  • Stress concentrations in bone cement : a critical distance approach 

    Hoey, David (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)
    Bone cement is a biomaterial which is used in the fixation of orthopaedic implants. Despite its extensive use it is regarded as the 'weak link' in cemented arthroplasties, fatigue failure of the cement mantle being a major ...
  • Targeted bone remodelling : investigating the scissors model 

    Dooley, Clodagh M. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)
    Bone is continually being removed and replaced through the actions of basic multicellular units (BMU). This constant upkeep is necessary to remove microdamage and thus maintain the integrity of the bone. Microdamage forms ...
  • Temporomandibular joint injuries during whiplash 

    Simms, Ciaran. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2000)
    Whiplash injuries occur due to differential accelerations in the human body. Neck injuries are predominant, but a considerable body of clinical evidence suggesting a close relationship between whiplash and temporomandibular ...
  • Tension and compression stress-strain asymmetry in passive skeletal muscle 

    Mohammadkhah, Melika (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)
    The general aim of this study is to advance the knowledge of the relationship between the skeletal muscle passive compressive and tensile behaviour, and the microstructure of the muscle through combined experimental, ...
  • The cellular transducer in damage-stimulated bone remodelling 

    Hazenberg, Jan Geert (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)
    People with osteoporosis, osteopenia or weight baring joint replacement, due to an altered loading configuration, are more susceptible to microdamage accumulation than normal human beings as are athletes who undertake ...
  • The developement of novel scaffolds for tissue engineering with a range of structural and mechanical properties 

    Haugh, Matthew George (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)
    Tissue engineering (or regenerative medicine) is defined as the application of scientific principles to the synthesis of living tissues using bioreactors, cells, scaffolds, growth factors, or a combination (Rose and Oreffo, ...
  • The development of a surface acoustic wave strain sensor 

    Donohoe, Brian (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    Multi sensors networks are becoming increasingly prevalent in modern engineering applications. In multi sensor networks, wireless sensors are preferred over traditional wired methods. Sensors based upon the surface acoustic ...
  • The development of a vibro-acoustic model of the human ear 

    McAvoy, G. J. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 1995)
  • The development of an active implantable neural probe system for chronic use 

    Frey, Laura Constance (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)
    The alleviation of symptoms of debilitating neural conditions via neural probes is an increasingly important area of research. However, the effectiveness of these probes decreases over time due to the formation of a glial ...
  • The effect of bone turnover on bone quality and material properties 

    Kennedy, Oran D. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)
    Coined in French in the 1820s as a description of a pathological state of bone tissue, the term osteoporosis made its way into the English language only in the 20th century. Unlike other medical concepts, which have not ...
  • The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold 

    McMahon, Louise Ann (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)
    Adult mesenchymal stem cells (MSCs) offer great potential in tissue engineering applications as they can be directed to differentiate along numerous lineages to produce a range of skeletal tissues, including the chondrogenic ...
  • The effect of stress concentrations on fatigue and fracture of 316L stainless steel micro-scale components 

    Wiersma, Susanne Amanda (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)
    The aim of this work was to investigate the fatigue and fracture behaviour of microscopic specimens based on a biomedical component (the cardiovascular stent) and to modify existing theories to take account of the observed ...
  • The effects of a sliding air bubble on heat transfer from an inclined surface 

    Donnelly, Brian (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    An investigation into the effect of a single sliding air bubble on heat transfer from a submerged, inclined surface has been performed. It is known that bubbles, both vapour and gas, can increase heat transfer rates from ...
  • The fatigue behaviour of three-dimensional stress concentrations 

    Bellett, Daniel (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2003)
    The fatigue behaviour of complex three-dimensional notched components is a subject of great practical interest to industrial engineers. Unfortunately, the analysis of this type of feature presents problems for most assessment ...
  • The influence of chevrons on the turbulent characteristics of jets 

    Kennedy, John (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2010)
    To minimize the significant environmental impact of air travel a reduction in noise pollution from jet engines is required. This has led to a renewed focus on active and passive techniques which modify the turbulence ...
  • The mechanics of wound closure for laparoscopic surgery 

    Lyons, Mathew (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    The increase in popularity of laparoscopic surgery over the past 25 years has led to a greater importance of reducing the incidence of complications associated with the surgery. Development of a hernia at a trocar port ...