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  • CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia 

    Hardiman, Orla (2016)
    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping, fatal neuro-degenerative disorders in which the molecular and pathogenic basis remains poorly understood. Ubiquitinated ...
  • Genetic screening in sporadic ALS and FTD 

    Hardiman, Orla (2017)
    The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least 10% of those diagnosed ...
  • Genetic testing in ALS: A survey of current practices 

    MCLAUGHLIN, RUSSELL; HARDIMAN, ORLA; Vajda, Alice; Heverin, Mark; Thorpe, Owen; Abrahams, Sharon; Al-Chalabi, Ammar (2017)
    Objective: To determine the degree of consensus among clinicians on the clinical use of genetic testing in amyotrophic lateral sclerosis (ALS) and the factors that determine decision-making. Methods: ALS researchers ...
  • Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis 

    Nasseroleslami, Bahman; Hardiman, Orla (2019)
    Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including ...