Browsing Clinical Medicine (Scholarly Publications) by Subject "Ageing"
Now showing items 1-20 of 25
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Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.
(2014)Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing in the elderly. Phagocytosis is an essential process in both wound healing and ... -
Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
(2014)Background Amyotrophic lateral sclerosis shares characteristics with some cancers, such as onset being more common in later life, progression usually being rapid, the disease affecting a particular cell type, and showing ... -
?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)Background: Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of ... -
Changes in urinary metabolomic profile during relapsing renal vasculitis
(2016)Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal vasculitis flare, we analysed the longitudinal urinary metabolomic ... -
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with ... -
?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and ... -
An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013).
(2014)Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ... -
The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders.
(2016)Background: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited. Objectives: The Trinity, Ulster, Department ... -
High prevalence of dementia among community dwelling older adults in receipt of state funded home care packages: implications for health care planning
(2017)Objectives: The majority of people living with dementia in Ireland reside in their own homes, some supported by formal or informal home care. This audit aimed to estimate the prevalence of dementia and suspected cognitive ... -
IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration
(2014)Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to ... -
Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community-Dwelling Older Adults
(2017)Background: The burden of chronic kidney disease is highest among older adults but the significance of a diminished level of kidney function in this heterogeneous population is poorly understood. We sought to examine ... -
The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs.
(2017)Background: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurological condition that requires coordinated, multidisciplinary clinical management. ALS is prone to misdiagnosis as its signs and symptoms may be ... -
Physical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based Case Control Study
(2014)OBJECTIVE: To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). METHODS: From February 2008 to April 2012, 652 patients with ALS from European population-based registries ... -
Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture - a systematic review
(2015)Background Recent quantitative neuroimaging studies have been successful in capturing phenotype and genotype-speci fi c changes in dementia syndromes, amyotrophic lateral sclerosis, Parkinson ’ s disease and other ... -
Prevalence of frailty among community dwelling older adults in receipt of low level home support: a cross-sectional analysis of the North Dublin Cohort
(2017)Background: There is increasing demand for formal government funded home help services to support community-dwelling older people in Ireland, yet limited information exists on the health profiles of this group, especially ... -
?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
The relationship between syncope, depression and anti-depressant use in older adults
(2014)The authors aim to examine the rates of depression in older patients reporting syncope and the effect of anti–depressants (ADs) on the rates of syncope. This study demonstrates an increased risk of syncope in patients with ... -
Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people.
(2011)BACKGROUND: Ireland is at 53°N, and its population risk of vitamin D deficiency is high. Previous Irish studies suggested a significant seasonality of serum 25-hydroxyvitamin D [25(OH)D] and a beneficial effect of ...
