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  • An investigation of T lymphocyte migration induced by CD44 activation 

    Fanning, Áine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    This thesis investigates the role of CD44 in signalling active migration in T lymphocytes. A number of murine studies have demonstrated that loss of CD44 expression by T lymphocytes resulted in a delayed migration to sites ...
  • Characterization of the outer membrane vesicles of the gastric pathogen Helicobacter pylori 

    Brown, Paul Alexander (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)
    The aim of the present study was to investigate the structure and composition of H. pylori outer membrane vesicles (OMVs) and to functionally characterize several OMV-associated pathogenic activities. Initial studies ...
  • Conjugated lineolic acid and insulin sensitivity : insights from metabolic and molecular markers 

    Moloney, Fiona (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Insulin resistance signifies an impaired biological response to insulin, and usually implies resistance to the effects of insulin on glucose uptake, metabolism, or storage. This defect is commonly observed in type 2 diabetes ...
  • Investigation of the role of RACKI in T lymphocyte migration 

    Rudolph, Christine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)
    Induction of the innmune response and production of pro-inflammatory cytokines results in the upregulation of ICAM-1 expressed on endothelial cells. Binding of ICAM-1 to the β2 integrin receptor LFA-1 on T cells induces T ...
  • Molecular mechanisms of resistance to therapeutic MEK inhibition in BRAF [V600E] cancer 

    Dorris, Emma R. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)
    Aberrant activation of the mitogen activated protein kinase (MAPK) pathway is common in solid tumours. This hierarchical pathway consists of a three-tiered kinase casade of BRAF, MAPK kinase (MEK1/2) and the extracellular ...