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  • An investigation into novel components and signalling mechanisms of inflammasomes 

    Becker, Christine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)
    This thesis concerns an analysis of caspase-1 and ASC, key components of the inflammasome. At the outset Rab39a had been found in a complex with caspase-1. Rab39a is a member of the Rab GTPase family, a group of proteins ...