Browsing Clinical Medicine (Theses and Dissertations) by Title
Now showing items 171-190 of 224
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Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to development of oesophageal adenocarcinoma (OAC), through a premalignant lesion, Barrett's oesophagus (BO). OAC has a 5-year survival of patients ... -
Renal function, cardiovascular disease and long term outcome in different cohorts of the Glasgow population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Over the past ten to fifteen years, the interaction between cardiovascular disease and chronic kidney disease (CKD) has come under increased scrutiny. Traditional cardiovascular risk factors are also associated with the ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ... -
Role of von Willebrand factor glycans in modulating susceptibility to ADAMTS13 proteolysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet tethering at sites of vascular injury. VWF adhesive function is dependent upon multimeric composition, which is regulated in plasma by ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
Steroid resistance and Inflammatory bowel disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Background: Steroid resistance remains a significant issue amongst IBD patients and mechanisms of resistance remain poorly understood. Endogenous Glucocorticoid metabolism may represent a key regulatory pathway in IBD. ... -
Studies on methotrexate cytotoxicity and apoptosis in human B-lymphocyte cell lines : with emphasis on 5,10-methylenetetrahydrofolate reductase 677C→T genotype and folate status
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Methotrexate (Mtx) is an antifolate drug which is widely used in treatment of cancer and of autoimmune and inflammatory conditions. The main mechanism by which Mtx operates is inhibition of dihydrofolate reductase (DHFR), ... -
Studies on the interaction of Helicobacter pylori with extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Helicobacter pylori is a common human pathogen that persistently colonises the stomach of half the worlds population. The majority of people infected with H. pylori are asymptomatic, however, a proportion develop severe ... -
A study of the clinical impact and outcomes of pharmacist-led interventions in the outpatient model of care for Hepatitis C patients in Ireland and their development into a novel complex intervention toolkit
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Given the high rates of sustained virological response and good tolerability of direct-acting antiviral regimens, international guidelines now recommend that all Hepatitis C infected patients be considered for access to ... -
Surface layer proteins of Clostridium difficile as novel vaccine candidates
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Clostridium difficile is a major cause of antibiotic associated diarrhoea and pseudomembranous colitis in hospitalised patients. The major precipitating factor for C. difficile-associated disease (CDAD) is disruption of ... -
Synthesis and characterisation of aerosolised MIF inhitibitors for the treatment of respiratory disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)The main focus of this PhD thesis was to investigate the synthesis and characterisation of an aerosolised poly lactic-co-glycolic acid (PLGA) nanodrug delivery system for MIF enzyme inhibitors to modulate the physiological ... -
Syphilis and HIV co-infection in Dublin; strategies to enhance diagnosis, investigation and management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Following historically low levels of reported cases of syphilis in Dublin in the 1990s there was a large outbreak of syphilis reported in 2001. Numerous interventions were implemented and the rates again decreased in 2003. ... -
The application of metabolomics to human nutrition research
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Background: Recent developments in analytical technologies and bioinformatics are driving modem advances in biological research. Many of these methods will have particular relevance in the field of nutrition. Among these ... -
The clinical characterisation and genetic epidemiology of familial ALS in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The overall objective of this thesis is to collate the existing literature on familial ALS and to address shortcomings in the research, to investigate aggregation of ALS and other conditions among relatives of patients ... -
The effects of conjugated linoleic acid on the human immune system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)The cells of the immune system are sensitive to their exogenous environment. Indeed the amount and type of nutrients, including fatty acids, which this environment contains all influence subsequent immune cell functioning. ... -
The effects of dietary fat and genotype on insulin sensitivity : the LIPGENE Dietary Intervention Study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Metabolic Syndrome (MetS) is characterised by hyperinsulinaemia, low glucose tolerance, dyslipidaemia (increased triacylglycerol, (TAG) and non-esterified fatty acids (NEFA) and reduced high density lipoprotein ... -
The epidermal growth factor (EGFR) in non-small cell lung cancer (NSCLC) : biomarker and therapeutic target
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Extract from Introduction: Lung cancer is the leading cause of cancer death in industrialized nations (Parkin, Bray et al. 2005). With approximately 1.35 million people diagnosed with the disease worldwide each year, and ... -
The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both ... -
The immune response to Hepatitis C host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Immune response to Hepatitis C; Host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source. A coordinated response from both the innate and adaptive arms of ... -
The immunogenetics of Hepatitis C Virus in a defined unique cohort
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Hepatitis C virus is a major cause of liver-related morbidity and mortality worldwide as chronic infection develops in up to 80% of those infected and leads to end-stage liver disease in a significant percentage. The ...
