Browsing Clinical Medicine (Theses and Dissertations) by Title
Now showing items 108-127 of 162
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Obesity, insulin resistance and Type 2 Diabetes in young Irish people
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I ... -
Ocular Microtremor as a clinical and scientific tool in neurologic disease : validation and application of a generalised discovery protocol
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Ocular microtremor (OMT) , a high frequency low amplitude eye movement, is one of three fixational eye movements present even when the eyes are apparently at rest. The tremor is thought to be related to tonic neural ... -
Ocular microtremor measurement, characterization & analysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Ocular Microtremor (OMT) is a high frequency tremor of the eye present in all normal subjects even if the eye is apparently still. It is one of the fixational eye movements. Changes in the OMT frequency and pattern have ... -
Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ... -
Orthostatic Hypotension as a marker of Frailty in Older People
(Trinity College Dublin, School of Medicine, Department of Medical Gerontology, 2011)This doctoral investigation endeavoured to explore the association between orthostatic hypotension (OH) and frailty in community-dwelling older people, in order to assess the validity of to-date untested, clinically grounded ... -
P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
Pain sensitivity in general practice
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 1957)This investigation was carried out during the ordinary routine work of general practice. It consisted of applying a simple test and considering the result in relation to the general clinical picture. The test is performed ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
Physical activity level and barriers to physical activity among an adult type 1 diabetes population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Context: Information on physical activity (PA) levels and its association with glycaemic control and cardiovascular disease (CVD) risk is lacking among Irish adults with T1DM. Aims: (1) PA levels were assessed in this ... -
Post operative atrial fibrillation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ... -
Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ... -
Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ... -
Protein Kinase Cη : regulation of expression and functional role in human T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Protein kinase Cη (PKCη) is a member of the novel PKC subfamily of serine/threonine kinases that has been shown to play critical roles in cell differentiation, proliferation, secretion and apoptosis in several cell types. ... -
Proteomic and cell based approaches for the study of the intestinal epithelial response to Helicobacter pylori soluble components in an ex vivo model of ulcerogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The aim of the present study was to investigate the effects of secreted components of the gastrointestinal pathogen H. pylori on the duodenal epithelium in humans. The effects of H. pylori are not only mediated by direct ... -
Renal function, cardiovascular disease and long term outcome in different cohorts of the Glasgow population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Over the past ten to fifteen years, the interaction between cardiovascular disease and chronic kidney disease (CKD) has come under increased scrutiny. Traditional cardiovascular risk factors are also associated with the ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ... -
Role of von Willebrand factor glycans in modulating susceptibility to ADAMTS13 proteolysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet tethering at sites of vascular injury. VWF adhesive function is dependent upon multimeric composition, which is regulated in plasma by ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
Studies on methotrexate cytotoxicity and apoptosis in human B-lymphocyte cell lines : with emphasis on 5,10-methylenetetrahydrofolate reductase 677C→T genotype and folate status
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Methotrexate (Mtx) is an antifolate drug which is widely used in treatment of cancer and of autoimmune and inflammatory conditions. The main mechanism by which Mtx operates is inhibition of dihydrofolate reductase (DHFR), ... -
Studies on the interaction of Helicobacter pylori with extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Helicobacter pylori is a common human pathogen that persistently colonises the stomach of half the worlds population. The majority of people infected with H. pylori are asymptomatic, however, a proportion develop severe ...
