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Now showing items 102-121 of 163

  • Nanomedicines for the treatment of coagulation disorders 

    Maguire, Ciarán Manus (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)
    Nanomaterials are becoming increasingly utilised in all areas of science, technology and healthcare. More specifically in terms of nanomedicine, the physical and chemical properties of the materials allow for application ...
  • The nerve of facial expression, impact of its anatomical variations on iatrogenic surgical injury and a novel MRI diffusion weighted imaging technique to image its intra-parotid course 

    EL KININY, WALID HOSAM (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)
    This doctorate in clinical medicine set out to assess how variations in facial nerve anatomy to the intra-parotid venous system could impact on surgical access to the parotid gland or the mandible, and explored methods to ...
  • New biochips for a three-dimensional study of transendothelial leukocyte migration 

    Toetsch, Stéphanie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)
    An important step in the inflammatory response is the recruitment of leukocytes into tissues through the endothelial cells which line blood vessels. Transendothelial migration (TEM) is the result of a multistep cascade in ...
  • Novel mediators regulating innate and adaptive type 17 immune responses 

    Russell, Shane E. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)
    The discovery of a third subset of T helper cells and more recently innate T cell subsets which preferentially express IL-17A has led to intensive investigation into the roles these cells play in both host defence and ...
  • Novel molecular targets in advanced prostate cancer 

    GREENE, JOHN PATRICK (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)
    Prostate Cancer (PCa) is the most commonly diagnosed cancer in men and a leading cause of morbidity and mortality among men in the United States and Western Europe. The aim of initial treatment in advanced PCa is to reduce ...
  • Novel Screening Strategies for HIV, Hepatitis B and C Infection 

    O'CONNELL, SARAH (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)
    Abstract Title: Novel Screening Strategies for HIV, Hepatitis B and C Infection. Author: Dr Sarah O?Connell Introduction: Despite prevention measures in place, rates of HIV infection have failed to decline in Ireland in ...
  • Nutritional aspects of trans unsaturated fatty acids 

    Cantwell, Mary Margaret (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)
    Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ...
  • Obesity, insulin resistance and Type 2 Diabetes in young Irish people 

    Finucane, Francis (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)
    The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I ...
  • Ocular Microtremor as a clinical and scientific tool in neurologic disease : validation and application of a generalised discovery protocol 

    Collins, Niamh E. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)
    Ocular microtremor (OMT) , a high frequency low amplitude eye movement, is one of three fixational eye movements present even when the eyes are apparently at rest. The tremor is thought to be related to tonic neural ...
  • Ocular microtremor measurement, characterization & analysis 

    Ali Al-Kalbani, Mohammed (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)
    Ocular Microtremor (OMT) is a high frequency tremor of the eye present in all normal subjects even if the eye is apparently still. It is one of the fixational eye movements. Changes in the OMT frequency and pattern have ...
  • Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease 

    TIGHE, DONAL (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ...
  • Orthostatic Hypotension as a marker of Frailty in Older People 

    Romero Ortuno, Roman (Trinity College Dublin, School of Medicine, Department of Medical Gerontology, 2011)
    This doctoral investigation endeavoured to explore the association between orthostatic hypotension (OH) and frailty in community-dwelling older people, in order to assess the validity of to-date untested, clinically grounded ...
  • P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease 

    Hennessy, Martina Joan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)
    P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ...
  • Pain sensitivity in general practice 

    Smith, Robert (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 1957)
    This investigation was carried out during the ordinary routine work of general practice. It consisted of applying a simple test and considering the result in relation to the general clinical picture. The test is performed ...
  • Particulate air pollution and mortality in Dublin 1980-1996 

    Goodman, Patrick Gerard (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)
    Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ...
  • Physical activity level and barriers to physical activity among an adult type 1 diabetes population 

    FINN, MARY (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)
    Context: Information on physical activity (PA) levels and its association with glycaemic control and cardiovascular disease (CVD) risk is lacking among Irish adults with T1DM. Aims: (1) PA levels were assessed in this ...
  • Post operative atrial fibrillation 

    Cosgrave, John (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ...
  • Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus 

    MCGOWAN, ANNE NOELLE (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)
    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ...
  • Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection 

    McKenna, Cormac (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)
    The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ...
  • Protein Kinase Cη : regulation of expression and functional role in human T lymphocytes 

    Nierop, Denise Triglia van (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)
    Protein kinase Cη (PKCη) is a member of the novel PKC subfamily of serine/threonine kinases that has been shown to play critical roles in cell differentiation, proliferation, secretion and apoptosis in several cell types. ...