Browsing Clinical Medicine (Theses and Dissertations) by Title
Now showing items 214-233 of 299
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P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
The Pathological Associations of Hyperuricaemia in Sub-Clinical Gout, Cardiovascular and Cardiopulmonary Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Abstract - Introduction Gout is a common and treatable disease caused by the deposition of MSU crystals in articular and non-articular structures. Hyperuricaemia is the most important risk factor for the development of ... -
Personalised Medicine in ANCA-Associated Vasculitis: The Role of Urine Soluble CD163
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)In this thesis I have identified a highly sensitive and specific association between urinary sCD163 and active renal vasculitis in the clinical setting of renal vasculitis flare in both retrospective and prospective studies. ... -
Physical activity level and barriers to physical activity among an adult type 1 diabetes population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Context: Information on physical activity (PA) levels and its association with glycaemic control and cardiovascular disease (CVD) risk is lacking among Irish adults with T1DM. Aims: (1) PA levels were assessed in this ... -
Physical function in community-dwelling older adults - a focus on health inequality and ageing in place
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis sought to explore socioeconomic determinants of physical function in community-dwelling older adults, with implications for ageing in place. While several markers of physical function are explored in this thesis, ... -
Physical functioning and health-outcomes following hospitalisation with COVID-19: a longitudinal cohort study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction: A novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) emerged in Wuhan, China in late 2019, causing an outbreak of viral pneumonia. Initial studies published focused on the management ... -
The Plasticity of Neutrophil Subsets in Inflammation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neutrophils are a vital component of the innate immune system and the body s first line of defense against invading pathogens. The classic view of these cells is that they are a homogenous population of terminally ... -
Platelet activation status, on-treatment platelet reactivity and reticulated platelets in the early and late phases after TIA/ischaemic stroke
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Aims: This thesis aimed to assess platelet activation status, on-treatment platelet reactivity and the profile of reticulated platelets in patients with ischaemic cerebrovascular disease (CVD) who were commencing or changing ... -
Polyunsaturated fatty acids, macrophages, and mediators of atherosclerosis: an in vitro investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Many cells are involved in the atherosclerotic process, but macrophages are present inevery phase of atherosclerosis and are heavily implicated as prime culprits in the molecular events that initiate, promote and complicate ... -
Post operative atrial fibrillation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ... -
Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ... -
Postprandial lipoprotein metabolism in diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Cardiovascular disease is up to four times greater in patients with Type 2 diabetes compared with nonnoglycaemic individuals (Pyorala et al., 1987; Laakso and Lehto 1997). Abnormalities in lipid metabolism may, in part, ... -
A Precision Medicine Approach to Dosing and Management of Continuous Renal Replacement Therapy for Acute Kidney Injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Despite decades of research, the mainstay of treatment for severe acute kidney injury (AKI) in the critical care setting remains renal replacement therapy in the form of dialysis. Continuous renal replacement ... -
Predictive Microbiome Post-Bone Marrow Transplantation and Acute Graft versus Host Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemopoietic stem-cell transplantation serves as one of the life-saving options for the management of refractory haematological malignancies and rarely for non-malignant conditions. The era of transplantation has significantly ... -
Profiles of von Willebrand factor antigen, von Willebrand factor propeptide and ADAMTS13 activity in patients with carotid stenosis and their relationship with cerebral micro-embolic signal status
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Aims: The aims of this thesis were to comprehensively investigate the profiles of von Willebrand Factor (VWF:Ag), von Willebrand Factor propeptide (VWFpp) and A Disintegrin And Metalloprotease with ... -
Profiles of von Willebrand factor antigen, von Willebrand factor propeptide and ADAMTS13 activity in patients with ischaemic cerebrovascular disease after commencing or changing antiplatelet therapy
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: There are very limited data on the impact of commonly-prescribed antiplatelet regimens on von Willebrand Factor antigen (VWF:Ag), von Willebrand Factor propeptide (VWFpp) and A Disintegrin And Metalloprotease ... -
Prospective Study of a Novel Diagnostic Algorithm for Investigating and Managing Gastrointestinal Disease Through The Appropriate Use of Biomarkers and Wireless Based Capsule Endoscopy
This chapter gives a general outline of the thesis for better understanding of issues surrounding research areas and studies that have been performed. Lower Gastrointestinal (GI) Symptoms are common and often warrant further ... -
Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ... -
Protein Kinase Cη : regulation of expression and functional role in human T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Protein kinase Cη (PKCη) is a member of the novel PKC subfamily of serine/threonine kinases that has been shown to play critical roles in cell differentiation, proliferation, secretion and apoptosis in several cell types. ...