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  • Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation 

    Finlay, David; Jones, Nicholas; Vincent, Emma E.; Cronin, James G.; Panetti, Silvia; Chambers, Megan; Holm, Sean R.; Owens, Sian E.; Francis, Nigel J.; Thornton, Catherine A. (2019)
    Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of ...