Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 252-271 of 724
-
Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development.
(2004)Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. ... -
Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses.
(2014)TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of ... -
The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3
(2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Hepatitis C Virus targets the Interferon-? JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.
(2013)JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-α signalling. We found ... -
Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver
(2021)5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate species; a re- action catalyzed by the mitochondrial ALA synthase 1 (ALAS1) enzyme. Previously we reported that knockdown of ... -
The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19
(2021)The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths worldwide since its outbreak. Public health responses have focused on identifying symptomatic individuals to halt spread. However, evidence ... -
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
(1999)In this study, we compared the influence of two peptides on the selection of CD8alphaalpha and CD8alphabeta intraepithelial lymphocytes (IELs) of the intestine, which develop by a unique and partially thymus-independent ... -
High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal
(2011)Background: The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's ... -
High-throughput Automated System for Crystallizing Membrane Proteins in Lipidic Mesophases.
(2007)A high-throughput robotic system has been developed to enable the automatic handling of nanoliter volumes of highly viscous biomaterials for crystallizing membrane proteins using lipidic mesophases. The in meso method ... -
A highly efficient blocked Gibbs sampler reconstruction of multidimensional NMR spectra
(2010)Projection Reconstruction Nuclear Magnetic Resonance (PR-NMR) is a new technique to generate multi-dimensional NMR spectra, which have discrete features that are relatively sparsely distributed in space. A small number ... -
Histological changes associated with wheat protein antibodies in the absence of villous atrophy.
(1987)A retrospective study was conducted to assess the association of alpha-gliadin antibodies with intraepithelial lymphocyte counts. Twelve subjects with apparently normal small intestinal histology and raised alpha-gliadin ... -
The history of Toll-like receptors-redefining innate immunity
(2013)The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, ... -
Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase
(2014)The lipid-based bicontinuous cubic mesophase is a nanoporous membrane mimetic with applications in areas that include medicine, personal care products, foods and the basic sciences. An application of particular note concerns ... -
Host Lipid and Temperature as Important Screening Variables for Crystallizing Integral Membrane Proteins in Lipidic Mesophases. Trials with Diacylglycerol Kinase
(2013)A systematic study of the crystallization of an α-helical, integral membrane enzyme, diacylglycerol kinase, DgkA, using the lipidic cubic mesophase or in meso method is described. These trials have resulted in the production ... -
How metabolism generates signals during innate immunity and inflammation
(2013)The interplay between immunity, inflammation, and metabolic changes is a growing field of research. Toll-like receptors and NOD-like receptors are families of innate immune receptors, and their role in the human immune ... -
How tumour necrosis factor blockers interfere with tuberculosis immunity.
(John Wiley, 2010)Tumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling
(2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
HUMAN INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE-2 (IRAK-2) IS ESSENTIAL FOR TOLL-LIKE RECEPTOR-MEDIATED TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF TNFα
(2011)Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NF?B and MAPKs such ...
