Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 222-241 of 724
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FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
(2014)Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by mutations in the FLCN gene and characterized by benign hair follicle tumors, pneumothorax, and renal cancer. Folliculin (FLCN), the protein ... -
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.
(Elsevier, 2009)Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated ... -
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
(2021)Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic ... -
Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226
(BioMed Central, 2006)BACKGROUND: Glycogen Synthase Kinase-3 (GSK3) activity is repressed following insulin treatment of cells. Pharmacological inhibition of GSK3 mimics the effect of insulin on Phosphoenolpyruvate Carboxykinase (PEPCK), ... -
Functional Group and Substructure Searching as a Tool in Metabolomics
(2008)Background: A direct link between the names and structures of compounds and the functional groups contained within them is important, not only because biochemists frequently rely on literature that uses a free-text format ... -
A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis
(2007)Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens1, 2, 3. The adaptor protein Mal (also known as TIRAP), encoded ... -
Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation
(2014)Protein N-glycosylation is a common post-translational modification that produces a complex array of branched glycan structures. The levels of branching, or antennarity, give rise to differential biological activities for ... -
Gating topology of the proton-coupled oligopeptide symporters
(2015)Peptide transport is the main route through which the body absorbs and retains dietary protein and hence plays an important role in human physiology (Steinhardt and Adibi, 1986). The combined action of acid hydrolysis in ... -
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
(American Society of Hematology, 2003)A modestly elevated total plasma homocysteine concentration (tHcy) is generally accepted as an independent and graded risk factor for various pathologies, including vascular diseases, neural tube defects, Alzheimer disease, ... -
Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene
(2013)The enteropathogen Campylobacter jejuni is a major worldwide health and economic burden, being one of the leading causes of bacterial gastroenteritis and commonly linked to postinfectious onset of autoimmune disease. ... -
Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
(2011)Background: Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact. Recent studies have highlighted the role of functional genomics to better ... -
Genotype variation at the MSTN locus is associated with skeletal muscle Coenzyme Q level in untrained Thoroughbred horses.
(2019)In the finely-tuned athletic species of Thoroughbred horses, polymorphisms (Intro 1 SNP g.66493737C>T and SINE insertion 227bp in promoter) in the myostatin gene (MSTN), a pronounced inhibitor of skeletal muscle growth, ... -
Gliadin antibody detection in gluten enteropathy.
(1986)Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be ... -
Global gene expression analysis of chicken caecal response to Campylobacter jejuni
(Elsevier, 2011)Campylobacter jejuni colonises the caecum of more than 90% of commercial chickens. Even though colonisation is asymptomatic, we hypothesised that it is mediated by activation of several biological pathways. We therefore ... -
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like
(2008)Phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) is essential for the induction of promoters which contain the interferon-stimulated response element (ISRE). IRF3 can be activated by Toll-like ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and ... -
GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources.
(2010)Background: The display of N-glycan carbohydrate structures is an essential part of glycoinformatics. Several tools exist for building such structures graphically, by selecting from a palette of symbols or sugar names, ...
