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dc.contributor.authorPrendergast, Patricken
dc.contributor.authorNOWLAN, NIAMH CATHERINEen
dc.contributor.authorMURPHY, PAULAen
dc.date.accessioned2008-06-03T11:46:56Z
dc.date.available2008-06-03T11:46:56Z
dc.date.issued2007en
dc.date.submitted2007en
dc.identifier.citationNowlan, NC, Murphy, P, Prendergast, PJ, Mechanobiology of embryonic limb development, Annals of the New York Academy of Sciences, 1101, 2007, 389, 411en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/16719
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 17344536en
dc.description.abstractConsiderable evidence exists to support the hypothesis that mechanical forces have an essential role in healthy embryonic skeletal development. Clinical observations and experimental data indicate the importance of muscle contractions for limb development. However, the influence of these forces is seldom referred to in biological descriptions of bone development, and perhaps this is due to the fact that the hypothesis that mechanical forces are essential for normal embryonic skeletal development is difficult to test and elaborate experimentally in vivo, particularly in humans. Computational modeling has the potential to address this issue by simulating embryonic growth under a range of loading conditions but the potential of such models has yet to be fully exploited. In this article, we review the literature on mechanobiology of limb development in three main sections: (a) experimental alteration of the mechanical environment, (b) mechanical properties of embryonic tissues, and (c) the use of computational models. Then we analyze the main issues, and suggest how experimental and computational fields could work closer together to enhance our understanding of mechanobiology of the embryonic skeleton.en
dc.description.sponsorshipSFIen
dc.format.extent389en
dc.format.extent411en
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesAnnals of the New York Academy of Sciencesen
dc.relation.ispartofseries1101en
dc.rightsYen
dc.subjectEmbryonic muscle contractionsen
dc.subjectcartilage differentiationen
dc.subjectimmobilizationen
dc.subjectcomputer modelingen
dc.subjectfinite element analysisen
dc.titleMechanobiology of embryonic limb developmenten
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pprenderen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pmurphy3en
dc.identifier.rssinternalid47401en
dc.identifier.doi10.1196/annals.1389.003en
dc.identifier.rssurihttp://onlinelibrary.wiley.com/doi/10.1196/annals.1389.003/epdfen


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