Now showing items 1-5 of 92

  • Synthesis of chemical probes targeting membrane proteins 

    REID, GERARD (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Membrane proteins carry out important physiological functions, including roles as enzymes and receptors, and are the targets for 50% of current drugs on the market,1 indicating their pharmacological importance. Knowledge ...
  • Inflammation and uterine disease in the postpartum dairy cow 

    BREWER, AMY ELIZABETH (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Following calving, inflammation of the uterus is common during the first week postpartum and is essential for the reparative process of involution. However, whilst the majority of cows resolve this inflammation a significant ...
  • Adjuvants targeting innate T lymphocytes for improved oral vaccination 

    ALBUTTI, AQEL SULAIMAN (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Effective mucosal vaccines can provide protective local and systemic immunity. Oral vaccination in particular has the potential to offer a safer and more efficacious approach than injection-based approaches, especially ...
  • Inhibitor of Apoptosis Proteins as Targets for the Treatment of Malignant Rhabdoid Tumours 

    COYLE, RACHEL (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Malignant rhabdoid tumor (MRT) is a rare paediatric cancer which unfortunately is highly refractive to treatment. Retrospective reviews commonly place the survival rate at approximately 30-35 %. Thus, there is an urgent ...
  • Investigating the role of specific inflammasome components during inflammatory disease 

    KENEALY, SINEAD (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Inflammasomes are multi-protein complexes that act as intracellular innate immune receptors. The first inflammasome was initially defined by Martinon et al in 2002 and 16 years on, this increasingly explored area has led ...