Now showing items 1-5 of 81

  • The establishment of hybrid cell lines from human pancreas 

    Reid, George W. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    The need for research into diabetes mellitus is ever increasing. Of specific interest are the mechanisms responsible for glucose-responsive insulin secretion and the autoimmune destruction of pancreatic p-cells. However, ...
  • Studies on human biliverdin-IX alpha reductase and linear tetrapyrrole signaling 

    Dunne, Aisling (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Human Biliverdin-IXa reductase (BVR-A) has been cloned and overexpressed in E.coli as a GST- and Hexahistidine fusion protein. The full length cDNA encoding the enzyme has been amplified via PCR and hgated into the pGEX-KG ...
  • Biochemical investigations of hyperhomocysteinemia 

    Betts, Mary Victoria (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first ...
  • Is Apolipoprotein-E modulated in peripheral blood mononuclear cells by IFN-β and is this to related patient responsiveness in multiple sclerosis 

    O'Toole, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Multiple Sclerosis is a neurodegenerative disorder involving the attack of blood resident T-lymphocytes on the myelin sheath surrounding the neuron. This condition is particularly prevalent amongst white, northern European ...
  • The role of thiols in the activation of the platelet integrin αllbβ3 

    O'Neill, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Platelets play a vital role in maintaining normal haemostasis. They circulate passively in the blood in an non-adhesive slate as discrete smooth discs. When platelets encounter a vessel wall injury or are exposed to foreign ...