Now showing items 1-5 of 85

  • The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function 

    O'CONNOR, EMMA BERNADETTE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. Our laboratory has reported evidence ...
  • Investigating the impact of natural killer (NK) cell metabolism on NK cell effector function 

    ZAIATZ BITTENCOURT, VANESSA (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    It is now known that metabolism, in addition to providing energy and biochemical building blocks, also regulates immune cell function. Over the last few years, we have increased our understanding of how NK cell metabolism ...
  • MicroRNA-21 Limits Macrophage Responses to Mycobacterium tuberculosis 

    HACKETT, EMER (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that subverts the innate immune response. The Mtb pandemic is of global concern. Emerging strains of antibiotic-resistant Mtb warrant the development of ...
  • Harnessing the therapeutic properties of the Heme Oxygenase system 

    CAMPBELL, NICOLE KAREN (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    The stress response enzyme, Heme Oxygenase 1 (HO-1), has been identified as an important immunomodulator which is highly upregulated in response to cellular stress and inflammation. HO-1 catalyses the conversion of free ...
  • The establishment of hybrid cell lines from human pancreas 

    Reid, George W. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    The need for research into diabetes mellitus is ever increasing. Of specific interest are the mechanisms responsible for glucose-responsive insulin secretion and the autoimmune destruction of pancreatic p-cells. However, ...