Browsing Biochemistry (Theses and Dissertations) by Sponsor "Wellcome Trust"
Now showing items 1-6 of 6
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Citrate, oxaloacetate and 2-hydroxyglutarate in the control of inflammatory macrophage activation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Immunometabolism is the study of changes that occur in the metabolic pathways of an immune cell during its activation. For macrophages, the remodelling of their metabolism following activation supports the adoption of ... -
The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ... -
Interactions Between Systemic Inflammation, Frailty And Neuroinflammation In Ageing And Neurodegeneration
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Compelling evidence continues to define the pivotal role which inflammation plays in the progression of neurodegenerative diseases and ageing. It has emerged that inflammation outside the brain significantly contributes ... -
Investigating the role of cell wall-anchored proteins during Staphylococcus aureus skin infection and as vaccine antigens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Staphylococcus aureus has become increasingly resistant to antibiotics and community acquired methicillin resistant S. aureus (CA-MRSA) skin and soft tissue infections (SSTIs) are occurring with increasing frequency in ... -
PKM2 regulation of metabolism but not transcription is important for natural killer cell responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating signal transduction and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the ... -
The role of IL-1 and Type I IFN in CNS function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Cytokines including interleukins (ILs) and interferons (IFNs) are induced in response to tissue injury, infection or inflammation. Peripheral cytokines signal to the healthy Central Nervous System (CNS) to produce ...