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  • Evaluation of the anti-cancer effects of a novel guanidinium-based compound, VP79s, in multiple myeloma 

    Amet, Rebecca (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
    Multiple myeloma (MM) is an incurable haematological malignancy accounting for 300-350 cancer diagnoses in Ireland each year. Mainly a disease of the elderly, MM is most prevalent in Western societies where aging populations ...
  • Inhibitor of Apoptosis Proteins as Targets for the Treatment of Malignant Rhabdoid Tumours 

    COYLE, RACHEL (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Malignant rhabdoid tumor (MRT) is a rare paediatric cancer which unfortunately is highly refractive to treatment. Retrospective reviews commonly place the survival rate at approximately 30-35 %. Thus, there is an urgent ...
  • Metabolic flux control of mitochondrial dynamics in cancer cells 

    MCGARRIGLE, RYAN (Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2017)
  • NK cell function and metabolism in human cancer 

    Slattery, Karen (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)
    Natural Killer (NK) cells are important anti-cancer innate immune cells. They are essential for cancer immunosurveillance and their activity is associated with better outcome in cancer patients. Some of their key ...
  • Particulate adjuvants for use in cancer vaccination 

    Ward, Ross (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
    It is estimated that 1 in 2 people will develop cancer in their lifetime, highlighting the urgent need for improved preventative and therapeutic strategies. Cancer immunotherapy has emerged as a key pillar of cancer ...