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  • T cells in experimental autoimmune encephalomyelitis 

    Lalor, Stephen (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)
    Multiple sclerosis (MS) is an intlammatory, demyelinating disease of the central nervous system (CNS) that is both clinically and pathologically heterogeneous. Studies in experimental autoimmune encephalomyelitis (EAE), ...
  • The alcohol dehydrogenases of Bacillus stearothermophilus 

    Robinson, Glynis A. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    A 1.5-kb fragment of Bacillus stearothermophilus DSM 2334 DNA was subcloned into pUC18, and the nucleotide sequence was determined. The fragment contained a complete open reading frame that encoded a 339-residue amino-acid ...
  • The characterisation of Human Vδ3 T cells 

    Mangan, Bo (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    Human γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analysed the frequencies, phenotypes, ...
  • The development of fish epithelial cell lines and primary cultures as diagnostic tools in environmental risk assessment 

    Dowling, Kevin J. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    The objective of the this study was to attempt and develop fish epithelial cellular markers as diagnostic tools for effects assessment in ecotoxicolgy using established cell lines and primary cultures. As a target group ...
  • The establishment of hybrid cell lines from human pancreas 

    Reid, George W. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    The need for research into diabetes mellitus is ever increasing. Of specific interest are the mechanisms responsible for glucose-responsive insulin secretion and the autoimmune destruction of pancreatic p-cells. However, ...
  • The glycosylphosphatidylinositol - phospholipase C (GPI-PLC) in bloodstream forms of Trypanosoma brucei 

    Hanrahan, Orla (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)
    The localization of the GPI-PLC in bloodstream form trypanosomes was investigated using confocal microscopy and surface labelling techniques, namely biotinylation and iodination. The confocal data indicate that the GPI-PLC ...
  • The human hepatocellular immune system and its role in regulating cancer 

    Fahey, Ronan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    The liver is an essential immunological organ receiving antigen-rich blood directly from the gut; a continuous immune exposure that requires careful immunosurveillance. It is considered to be a mainly tolerogenic organ as ...
  • The immunodulatory effects of the cAMP effector Epac 

    Lambe, Eimear M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Cyclic AMP is an extremely important second messenger and is known to be a central mediator of inflammation and regulator of the immune response. For many years it was thought that the effects of cAMP on immunity were ...
  • The immunomodulatory effects of NOD1 activation 

    Kelly, Patrick Joseph (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    NOD1 and NOD2 are cytosolic pathogen recognition receptors (PRRs) which detect peptidoglycan derivatives and contribute to the host defence during bacterial infection. Transgenic mice lacking NOD1 or NOD2 are susceptible ...
  • The influence of particle size in adjuvant induced innate and adaptive immune responses 

    Hearnden, Claire (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Advances in vaccine development have enabled the application of adjuvanted subunit vaccines as opposed to attenuated or killed whole organisms. However the efficacy of this approach is strongly dependent on the optimisation ...
  • The mechanism of action of particulate vaccine adjuvants 

    Sharp, Fiona A. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)
    Particulate vaccine adjuvants (PVA) have been used in vaccines both experimentally and clinically for almost a century. However, the mechanisms by which adjuvants, such as alum and poly lactide-co-glycolide (PLG) ...
  • The mechanistic characterisation of misfolding proteins in disease and cancer therapy 

    Harte, Níal (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Protein folding is a highly ordered and governed event which results in the production of native peptide structures capable of carrying out a myriad of functions and processes within the cell. Failure to produce fully ...
  • The pathogenesis of experimental autoimmune encephalomyelitis 

    Dungan, Lara (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Multiple Sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) mediated by autoantigen-specific T cells. Experimental autoimmune encephalomyelitis (EAE) is an animal model for MS driven by ...
  • The pathogenicity and regulation of CD161⁺Th17 lineage cells in rheumatoid arthritis 

    Basdeo, Sharee Ann (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Pathogenic Th17 cells, which produce their signature cytokine IL-17, play a key role in autoimmune diseases such as rheumatoid arthritis (RA) and therefore, have been the target of recently developed therapeutics. On the ...
  • The Queuine-Transfer RNA Pathway as a novel drug mechanism to treat Multiple Sclerosis 

    Varghese, Sreeja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Queuine is a pyrrolopyrimidine molecule that is irreversibly incorporated into the anticodon loop of transfer RNA (tRNA) for the amino acids Asparagine, Aspartate, Tyrosine and Histidine. Only bacteria synthesize queuine, ...
  • The relative role of IRAK-2 in TLR signalling 

    Flannery, Sinéad (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NFkB and MAPKs such as p38. ...
  • The role of amines in paraganglioma, neuroblastoma and carcinoid diagnosis 

    Tormey, William P. (Trinity College (Dublin, Ireland). Department of Chemical Pathology, 2000)
    The role of urinary noradrenaline, adrenaline, dopamine, 4-hydroxy-3-methoxy-mandelic acid (HMMA) and homovanillic acid (HVA) in the diagnosis of paraganglioma especially phaeochromocytoma and in neuroblastoma is investigated. ...
  • The role of Ets2 in the regulation of microRNA-155 

    Quinn, Susan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukaemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role of ...
  • The role of IL-1 in the induction of IL-17 producing T cells 

    Sutton, Caroline Eva (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)
    T helper cell responses have traditionally been divided into two distinct subsets, Th1 and Th2, producing IFN-y and IL-4 respectively. However, more recently the IL-12 family member, IL-23, has been shown to have a role ...
  • The role of Mal in alveolar macrophage-mediated resistance to Bordetella pertussis 

    Bernard, Nicholas J. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    There is a global resurgence in pulmonary infection with Bordetella pertussis, the causative agent of whooping cough. B. pertussis is known to encode a number of virulence factors, some of which can function as pathogen-associated ...