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Now showing items 204-223 of 289

  • Rational discovery of second generation anti-cancer ligands 

    Golfis, Georgia (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)
    Recently, a novel series of Pyrrolo-1,5-BenzOXazepine (PBOX) compounds have shown apoptotic activity upon numerous cancer cell lines. Importantly, they have been suggested as potential antineoplastic agents in particular ...
  • Re-evaluating the Role of SARM1 as a Transcriptional Regulator Using Improved Genome-Edited Mouse Models 

    Doran, Ciara (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    SARM1 is an ancient and highly conserved protein, initially described as having functions in innate immunity. In the last decade, our understanding of SARM1 structure and function expanded rapidly. The majority of research ...
  • Regulation of bovine beta-defensin expression 

    Barry-Reidy, Anne (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)
    Beta-defensins are a class of host defence peptides with antibacterial, antiviral and immunomodulatory roles. The bovine genome contains up to 57 putative beta-defensin genes in four syntenic clusters on different chromosomes. ...
  • Regulation of innate and adaptive immune responses by synthetic and pathogen-derived immunomodulatory molecules 

    Donnelly, Graham (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)
    The development of new and improved vaccine formulations for human use requires the discovery of efficacious non-toxic adjuvants that enhance immune responses to poorly immunogenic purified native or recombinant antigens. ...
  • Regulation of innate and adaptive immunity by the vaccine adjuvant alum 

    Oleszycka, Ewa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    While many licensed vaccines consist of whole or inactivated pathogens, there is a move toward vaccines based on purified antigens which although safer are generally less immunogenic and therefore require adjuvants to ...
  • Regulation of the immunomodulatory cytokine IL-10 by Twist2 

    Van den Bosch, Mirjam W. M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    Dysregulation of cytokines can lead to infectious and inflammatory diseases. The anti-inflammatory cytokine IL-10 is known to control pro-inflammatory cytokines such as TNF-a, IL-6 and IL-12. The regulation of IL-10 is ...
  • Regulatory T cell induction and function 

    Walsh, Kevin (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
    The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production ...
  • The role of Colony Stimulating Factor 1 Receptor in microglial phenotype and function in vitro and in vivo 

    Islam, Sadia (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    As the brain ages multiple cellular processes become less efficient leading to a decline in cognitive and other functions, and in many cases giving rise to chronic neurodegenerative conditions such as Alzheimer’s Disease ...
  • The role of dietary fat in anti-tumour immunity 

    Prendeville, Hannah Catherine (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Obesity increases the risk of many cancers and impairs immunosurveillance. However, little is known about whether the type of dietary fat affects tumour growth and anti-tumour immune responses. Here, we show that a ...
  • The role of IL-1 and Type I IFN in CNS function 

    MURRAY, CAROL (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    Cytokines including interleukins (ILs) and interferons (IFNs) are induced in response to tissue injury, infection or inflammation. Peripheral cytokines signal to the healthy Central Nervous System (CNS) to produce ...
  • Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease 

    McManus, Róisín M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ...
  • The Role of miR-155 in Myeloid cells during Experimental Autoimmune Encephalomyelitis 

    LYONS, VICTORIA (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
    Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterised by multifocal demyelinating lesions with associated neuronal damage. Although MS is a CD4+ T cell-mediated disease, ...
  • The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function 

    O'CONNOR, EMMA BERNADETTE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. Our laboratory has reported evidence ...
  • Role of the Elongator complex in innate immune responses of macrophages 

    Murphy, Jamie (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
    The innate immune system functions as the first line of defence against pathogen infection. Innate immune systems are functionally present across the animal kingdom and mediate host defence against infection via a myriad ...
  • The role of tissue-resident memory T cells in immunity to Bordetella pertussis 

    Curham, Lucy (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Whooping cough (pertussis) is a severe respiratory disease cause by the Gram-negative bacterium Bordetella pertussis. Despite high vaccine coverage, a resurgence of pertussis has been observed over recent years. Although ...
  • The roles of cytoplasmic aspartate aminotransferase in trypanosoma brucei 

    Barry, Paul (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)
  • Ruthenium(11) metal complexes for photodynamic therapy (PDT) or as imaging agents 

    Erby, Marialuisa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Photodynamic therapy (PDT) represents a new localised method of treatment in cancer. The therapeutic effect is mediated by the generation of reactive oxygen species (ROS) and/or the formation of singlet oxygen (1 O2), a ...
  • Schistosoma mansoni modulation of allergic responses 

    Mangan, Niamh (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    It has been proposed that in humans infection with certain parasitic helminths may reduce the propensity to develop allergies in infected populations. Schistosoma mansoni is a parasitic trematode that is implicated as a ...
  • Semicarbazide-sensitive amine oxidase & 5-HT in dental pulp 

    O'Sullivan, Michael (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    This thesis investigated the behavior of semicarbazide sensitive amine oxidase (SSAO) and the unique activity that it possesses towards 5-hydroxytryptamine (5-HT) in various dental pulp tissues. This summary presents the ...
  • Serotonin transporter ligands as anticancer agents : investigations into a mechanism-based therapy for Burkitt's lymphoma and related malignancies 

    Cloonan, Suzanne M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
    The recent discovery that some serotonin transporter (SERT) ligands have the potential to act as pro-apoptotic agents in Burkitt’s lymphoma adds greatly to their diverse pharmacological application and is the primary focus ...