Browsing Biochemistry (Theses and Dissertations) by Title
Now showing items 85-104 of 289
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Genetic variation in bulls divergent for fertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Bovine fertility remains a critical issue underpinning the sustainability of the agricultural sector. Since the realisation of an unfavourable relationship between fertility and production traits in cattle, methods to ... -
GlcNAc transferases and glycoengineering in Chinese hamster ovary cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Glycosylation constitutes one of the most important post-translational modifications of proteins, with over 60% of proteins known to be glycosylated. GlcNAc transferases (GnTs) belong to a large subfamily of glycosyltransferases ... -
Glycerol-3-phosphatase from Trypanosoma brucei brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Glycerol-3-phosphatase activity was found in both bloodstream and procyclic form o f trypanosomes with a specific activity of 35 nmol/min/mg of protein and 28 nmol/min/mg of protein respectively. The localisation of the ... -
Gone or Misplaced?: Investigation of Memory Engrams Across Development
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)All humans experience amnesia. While about 30% of adults who live to be over 65 will suffer from dementia, 100% of the human population experiences infantile amnesia, which is the loss of memories formed in early childhood ... -
HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Oral and oesophageal cancers are aggressive tumours that are frequently diagnosed late, with high morbidity, mortality, and difficulties in surgical and therapeutic intervention. Novel imaging probes could assist in early ... -
Harnessing the therapeutic properties of the Heme Oxygenase system
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The stress response enzyme, Heme Oxygenase 1 (HO-1), has been identified as an important immunomodulator which is highly upregulated in response to cellular stress and inflammation. HO-1 catalyses the conversion of free ... -
HCV evasion of IFN-alpha signalling : implications for therapy
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Successful anti-viral immunity is dependent on effective activation of the innate immune response. The majority of individuals infected with hepatitis C virus (HCV) fail to eliminate the virus and progress to chronic ... -
Helminth products promote anti-inflammatory trained innate immunity by imprinting long-term hematopoietic stem cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Recent research has shown that immunological memory is not confined to the cells of the adaptive immune system but can be imbued upon innate immune cells, including monocytes and macrophages, in a process known as trained ... -
The hepatic microenvironment and immune cell recruitment in colorectal liver metastasis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The liver is uniquely enriched with anti-tumour immune cells. However, liver metastasis is anticipated in over half of colorectal cancer patients. The value of the type and location of immune cells to prognosis has been ... -
HUMAN HEPATIC NATURAL KILLER CELLS IN HEALTH AND MALIGNANCY
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The adult human liver is described as an immunologically tolerogenic organ, maintaining a homeostatic environment while bombarded by dietary antigens, microbial products and metabolic by-products. The liver is also a site ... -
Identification and characterisation of proteins from the tomato lectin binding fraction of Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)African trypanosomes, of which Trypanosoma brucei may be considered a prototypic member, are protozoan parasites responsible for sleeping sickness in man and related diseases in cattle and other domestic animals. Although ... -
Identification and characterisation of serotonin transporter interacting proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)The serotonin transporter (SERT) is an integral plasma membrane protein that mediates the high-affinity re-uptake of the neurotransmitter serotonin from the synaptic space. SERT is of particular clinical and phannacological ... -
Identification of Anticoagulant Properties of Dimethyl Fumarate and 4-Octyl Itaconate via Suppression of the Macrophage Type I Interferon-Tissue Factor Axis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The host response to infection is characterized by activation of the innate immune and blood coagulation systems, which collectively detect, neutralize, and prevent dissemination of the invading pathogen, maintaining ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
Identification of the components of the eukaryotic queuine transglycosylase complex and the effect of its substrate queuine on metabolism
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Queuine is a 7-deazaguanine derivative of guanine, which replaces guanine in position 34 of the anticodon loop of the transfer RNA for the amino acids, asparagine, aspartic acid, histidine and tyrosine. This base or related ... -
Identification of the mammalian queuine transfer RNA ribosyltransferase complex and characterisation of QTRT1 gene-trap mice deficient in queuosine modified transfer RNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Queuine, or Q-base, is a modified form of 7-deazaguanine that is synthesised de novo by eubacteria, but which is obtained from food or the gut flora by eukaryotes. Q-base is enzymatically inserted into the wobble position ... -
IL-33 regulates the immune response to particulate vaccine adjuvants
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Vaccines are one of the most successful tools contributing to global health. Despite their success, further research into safe and efficient vaccination is required to address two key issues; to combat emerging infectious ... -
Immediate-Early-Gene (IEG) expression in excitotoxicity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)The mouse cerebellar granule cell system (mCGCs; Schousboe et al, 1989) was established in this laboratory (Bayer AG, Germany) as a suitable cell culture model for excitotoxicity studies. Suitability was confirmed by ... -
Immune dysfunction in the skin disease hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. Painful lesions and boils present at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Severe cases ... -
Immune modulation by the helminth parasite Fasciola hepatica
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)The incidence of allergic and autoimmune disease In the developed world has Increased dramatically In the past century. This has coincided with a reduction In the Incidence of infectious disease. The hygiene hypothesis ...