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dc.contributor.authorJOHNSON, KATHERINEen
dc.contributor.authorROBERTSON, IANen
dc.contributor.authorGILL, MICHAELen
dc.contributor.authorDAIBHIS, AOIFEen
dc.contributor.authorDALY, MICHAELen
dc.contributor.authorFITZGERALD, MICHAELen
dc.date.accessioned2008-03-29T19:09:26Z
dc.date.available2008-03-29T19:09:26Z
dc.date.issued2008en
dc.date.submitted2008en
dc.identifier.citationJohnson, K.A., Barry, E., Bellgrove, M.A., Cox, M., Kelly, S.P., Daibhis, A., Daly, M., Keavey, M., Watchorn, M., Fitzgerald, M., McNicholas, F., Kirley, A., Robertson, I.H., Gill, M, Dissociation in response to methylphenidate on response variability in a group of medication naïve children with ADHD, Neuropsychologia, 46, 5, 2008, 1532 - 1541en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/15318
dc.descriptionPUBLISHEDen
dc.description(243) PMID 18289615 ABSTRACT: Increased variability in reaction time (RT) has been proposed as a cardinal feature of attention deficit hyperactivity disorder (ADHD). Increased variability during sustained attention tasks may reflect inefficient fronto-striatal and fronto-parietal circuitry; activity within these circuits is modulated by the catecholamines. A disruption to dopamine signaling is suggested in ADHD that may be ameliorated by methylphenidate (MPH). This study investigated the effects of MPH administration on the variability in RT and error performance on a sustained attention task of a group of 31 medication naïve children with ADHD, compared with 22 non-ADHD, non-medicated, control children. All children performed the fixed-sequence sustained attention to response task (SART) at two time-points: at baseline and after six weeks. The children with ADHD were tested when medication naive at baseline and after six weeks of treatment with MPH and whilst on medication. The medication naïve children with ADHD performed the SART with greater errors of commission and omission when compared with the control group. They demonstrated greater standard deviation of RT and fast moment-to-moment variability. They did not differ significantly from the control group in terms of slow variability in RT. MPH administration resulted in reduced and normalised levels of commission errors and fast, moment-to-moment variability in RT. MPH did not affect the rate of omission errors, standard deviation of RT or slow frequency variability in RT. MPH administration may have a specific effect on those performance components that reflect sustained attention and top-down control rather than arousal.en
dc.description.abstractIncreased variability in reaction time (RT) has been proposed as a cardinal feature of attention deficit hyperactivity disorder (ADHD). Increased variability during sustained attention tasks may reflect inefficient fronto-striatal and fronto-parietal circuitry; activity within these circuits is modulated by the catecholamines. A disruption to dopamine signaling is suggested in ADHD that may be ameliorated by methylphenidate (MPH). This study investigated the effects of MPH administration on the variability in RT and error performance on a sustained attention task of a group of 31 medication naive children with ADHD, compared with 22 non-ADHD, non-medicated, control children. All children performed the fixed-sequence sustained attention to response task (SART) at two time-points: at baseline and after six weeks. The children with ADHD were tested when medication naive at baseline and after six weeks of treatment with MPH and whilst on medication. The medication naive children with ADHD performed the SART with greater errors of commission and omission when compared with the control group. They demonstrated greater standard deviation of RT and fast moment-to-moment variability. They did not differ significantly from the control group in terms of slow variability in RT. MPH administration resulted in reduced and normalised levels of commission errors and fast, moment-to-moment variability in RT. MPH did not affect the rate of omission errors, standard deviation of RT or slow frequency variability in RT. MPH administration may have a specific effect on those performance components that reflect sustained attention and top?down control rather than arousal.en
dc.description.sponsorshipThis work was supported by grants from the Irish Health Research Board, Science Foundation Ireland, Irish Higher Education Authority's Programme for Research in third-level Institutions. KAJ is supported by the Health Research Board of Ireland.en
dc.format.extent1532en
dc.format.extent1541en
dc.format.mimetypeapplication/msword
dc.language.isoenen
dc.relation.ispartofseriesNeuropsychologiaen
dc.relation.ispartofseries46en
dc.relation.ispartofseries5en
dc.rightsYen
dc.subjectResponse timeen
dc.subjectMethylphenidateen
dc.subjectAttention Deficit Hyperactivity Disorderen
dc.subjectADHDen
dc.subjectVariabilityen
dc.subjectDopamineen
dc.titleDissociation in response to methylphenidate on response variability in a group of medication naïve children with ADHDen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/johnsokaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/irobertsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mifitzgeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid48294en
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuropsychologia.2008.01.002en
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDTagADD/ADHDen
dc.subject.TCDTagADD/ADHDen
dc.subject.TCDTagADHDen
dc.subject.TCDTagADHDen
dc.subject.TCDTagADHD Lifetime Impairment Surveyen
dc.subject.TCDTagATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)en
dc.subject.TCDTagAdolescent Psychiatryen
dc.subject.TCDTagAttention Deficit Hyperactivity Disorder (ADHD)en
dc.subject.TCDTagCHILD PSYCHIATRYen
dc.subject.TCDTagCOMMUNITY PSYCHIATRYen
dc.subject.TCDTagCONSULTATION LIAISON PSYCHIATRYen
dc.subject.TCDTagCONSULTATION-LIAISON PSYCHIATRYen
dc.subject.TCDTagDISORDER ADHDen
dc.subject.TCDTagGENERAL HOSPITAL PSYCHIATRYen
dc.subject.TCDTagLIAISON PSYCHIATRYen
dc.subject.TCDTagMETHYLPHENIDATEen
dc.subject.TCDTagNeuropsychiatryen
dc.subject.TCDTagNeuropsychiatryen
dc.subject.TCDTagPSYCHIATRYen
dc.subject.TCDTagPsychiatryen
dc.subject.TCDTagPsychiatryen
dc.subject.TCDTagTRAINEES IN PSYCHIATRYen
dc.subject.TCDTagadult ADHDen
dc.subject.TCDTagchild and adolescent Psychiatryen
dc.subject.TCDTagneurodevelopmental psychiatryen
dc.identifier.rssurihttp://professormichaelfitzgerald.eu/en
dc.identifier.rssurihttp://www.ncbi.nlm.nih.gov/pubmed/18289615en


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