Browsing Physiology (Scholarly Publications) by Author "LYNCH, MARINA"
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α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
LYNCH, MARINA; LYNCH, MARINA ANNETTA (2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
LYNCH, MARINA; MILLS, KINGSTON (2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation
LYNCH, MARINA (2011)The family of reticulons include 3 isoforms of the Nogo protein, Nogo A, Nogo B and Nogo C. Nogo A is expressed on neuronal tissue and its primary effect is widely acknowledged to be inhibition of neurite outgrowth. Although ... -
Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
LYNCH, MARINA; MINOGUE, AEDIN (2014)Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
LYONS, ANTHONY; LYNCH, MARINA (2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Bimodal magnetic-fluorescent nanostructures for biomedical applications
KERSKENS, CHRISTIAN; GOUNKO, IOURI; LYNCH, MARINA (2009)Magnetite-based polyelectrolyte-coated nanostructures were fabricated and the potential for biomedical application assessed in mixed glial cell cultures with nanostructure cellular internalization, cytotoxicty and contribution ... -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
LYNCH, MARINA; MINOGUE, AEDIN; MINOGUE, AEDIN; LYNCH, MARINA ANNETTA (2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli
LYNCH, MARINA (2015)Background Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of macrophages. Whereas it is accepted that the immune system ... -
CD200 fusion protein decreases microglial activation in the hippocampus of aged rats
LYNCH, MARINA; COX, FRANCES FIONNUALA (2012)The glycoprotein, CD200, is primarily expressed on neurons and its cognate receptor CD200R is expressed principally on cells of the myeloid lineage, including microglia. The interaction of CD200 with its receptor plays a ... -
Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia.
LYNCH, MARINA; MURPHY, NIAMH; COSTELLO, DEREK; DOWNER, ERIC (2012)Background: The interaction between the membrane glycoprotein, CD200 and its cognate receptor CD200 receptor (CD200R), has been shown to play a role in maintaining microglia in a quiescent state. There is evidence of ... -
Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.
LYNCH, AILEEN; LYNCH, MARINA (2009)Several neurodegenerative disorders are associated with evidence of inflammation, one feature of which is increased activation of microglia, the most likely cellular source of inflammatory cytokines like interleukin-1b. ... -
How dependent is synaptic plasticity on microglial phenotype?
LYNCH, MARINA; LYNCH, MARINA ANNETTA (2015)Microglia are particularly plastic cells which can be shifted from their resting state by numerous factors and adopt distinct phenotypes. The cells are multifunctional, though their main role is probably maintenance of ... -
Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory
LYNCH, MARINA; MCDONALD, CLAIRE; ROBERTSON, IAN; BRENNAN, SABINA (2013)Background Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
LYNCH, MARINA; MILLS, KINGSTON (2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
The impact of aging on the brain - risk, resilience and repair
LYNCH, MARINA (2012)This Brief Commentary describes a Special Issue that features a series of papers that provide new data on how aging and inflammation interact to affect behaviors that are regulated by the dialogue between the immune system ... -
The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
LYNCH, MARINA (2013)Neuroinflammatory changes are a characteristic of several, if not all, neurodegenerative diseases including Alzheimer?s disease (AD) and are typified by increased microglial activation. Microglia express several receptors ... -
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
LYNCH, MARINA; O'NEILL, LUKE; MILLS, KINGSTON; FINUCANE, ORLA (2017) -
Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice
LYNCH, MARINA; MINOGUE, AEDIN (2015)There is a wealth of evidence indicating that macrophages adopt distinct phenotypes when exposed to specific stimuli and, in the past few years, accumulating data suggest that microglia behave somewhat similarly. Therefore, ... -
Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
LYNCH, MARINA; COSTELLO, DEREK; COX, FRANCES FIONNUALA; BROWNE, TARA; DENIEFFE, STEPHAINE; LYONS, ANTHONY (2011)The membrane glycoprotein CD200 is expressed on several cell types including neurons whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The interaction ... -
Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.
LYNCH, MARINA (2014)The intestinal microbiota is increasingly recognized as a complex signaling network that impacts on many systems beyond the enteric system modulating, among others, cognitive functions including learning, memory and ...