Browsing Physiology (Theses and Dissertations) by Subject "Molecular Neuropharmacology, Ph.D."

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  • Investigating the role of fractalkine an S1P receptors on oxidative stress in the CNS 

    O'Sullivan, Sineád (Trinity College (Dublin, Ireland). Department of Physiology, 2016)
    Scientific Abstract: The fractalkine ligand (CX3CL1) is a unique chemokine that is synthesised as a transmembrane protein. One of the unique features of fractalkine is its ability to exist as both a membrane tethered ...

  • The modulation of S1P receptor signalling and demyelination 

    Pritchard, Adam (Trinity College (Dublin, Ireland). Department of Physiology, 2014)
    Sphingosine 1-phosphate receptors are a family of G-protein coupled receptors (GPCRs) that consists of five subtypes (S1PR1-5). These receptors have emerged as therapeutic targets in multiple sclerosis (MS) due to the ...

  • The role of S1P receptors and their interacting proteins in Krabbe Disease 

    O'Sullivan, Catherine (Trinity College (Dublin, Ireland). Department of Physiology, 2015)
    Globoid cell leukodystrophy (Krabbe disease, KD) is a rare autosomal recessive neurodegenerative disorder that presents within the first six months of life and is usually fatal by the age of two years. KD is caused by a ...

  • The signalling and function of EB12 in the central nervous system 

    Rutkowska, Aleksandra (Trinity College (Dublin, Ireland). Department of Physiology, 2014)
    The four major brain-specific cell types in the brain are; (i) neurons, which transmit and process information via electrical signals, (ii) oligodendrocytes, which insulate neuronal axons with fatty sheets called myelin ...