Browsing Physiology (Theses and Dissertations) by Sponsor "Irish Research Council (IRC)"
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Assessing Toll-like receptor 3/4 signalling as a phytocannabinoid target in immune cells
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Toll-like receptors (TLRs) are the sensors of pathogen associated molecules that trigger tailored innate immune intracellular signalling responses. TLRs are expressed on cells of the immune system and play an important ... -
Investigating the role of mechanosensitive channel Piezo1 in the CNS
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)All cells in the organism are able to sense changes in the mechanical properties of their environment, translating them into chemical intracellular signals through a process termed mechanotransduction, mostly via ... -
An Investigation of Inflammatory and Metabolic Blood-Based Biomarkers of Cognitive Decline
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2018)Alzheimer’s disease (AD) and other dementias a re the main cause of cognitive impairment in older adults. AD is fast becoming a global epidemic, yet the development of a ...