Browsing Pharmacology & Therapeutics (Scholarly Publications) by Author "HU, NENG"
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GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
ROWAN, MICHAEL; ANWYL, ROGER; KLYUBIN, IGOR; HU, NENG (2010)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances
ROWAN, MICHAEL; ONDREJCAK, TOMAS; HU, NENG (2012)The cognitive and related symptoms of Alzheimer's disease are mainly attributable to synaptic failure. Here we review recent research on how the Alzheimer's disease amyloid ?-protein (A?) affects glutamate receptors and ...