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Now showing items 18-37 of 40

  • Metformin, aspirin, and colorectal cancer outcomes 

    Spillane, Susan Catherine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)
    Colorectal cancer is the second most incident cancer in men and women in Ireland and is the third greatest cause of cancer death. Metformin and aspirin, two drugs which are commonly used in type 2 diabetes and cardiovascular ...
  • Modelling compliance with antihypertensives and statins in Ireland, using a national prescription claims database 

    Fitz-Simon, Alexandra Nicola O'Connell (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    Hypertension and high cholesterol, especially in the middle-aged and elderly, are fairly common, and pharmacological therapy is often required to control them. In spite of substantial knowledge of the consequences of ...
  • Multiple sclerosis in Ireland : costs, health-related quality of life and cost effectiveness of disease-modifying therapies 

    Fogarty, Emer (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)
    This study aimed to evaluate the economic and health-related quality of life (HRQoL) burden of multiple sclerosis (MS) in Ireland, and to develop a framework for assessing the cost effectiveness of disease-modifying therapies ...
  • Neurotransmitter interactions in the control of spatial memory and exploratory activity in the rat 

    Amico, Francesco (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    The role of the central cholinergic system in learning and memory is well established, with many investigations reporting that central cholinergic hypofunction is correlated with impaired performance on various behavioural ...
  • Nuclear receptor activation by antiretroviral drugs used in the treatment of HIV disease with implications for xenobiotic and endobiotic processes 

    Svard, Jenny Sofia (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)
    Genotyping: DNA was isolated from whole blood of 1013 HIV-patients and genotyped commercially for 37 single nucleotide polymorphisms (SNPs) and one 3-basepair insertion in genes of relevance for drug interactions: NR1I2 ...
  • Pharmaceutical pricing and reimbursement : an Irish perspective 

    Tilson, Lesley H. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    There has been a five-fold increase in state expenditure on medicines under the Community Drug Schemes in Ireland over the last decade (1994 to 2004). As a result of this marked increase in pharmaceutical expenditure, the ...
  • Pharmacoeconomics of Statin Therapy in Ireland 

    Heerey, Adrienne Monica (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    Cardiovascular disease is the leading cause of death in most industrialised countries, including Ireland. Cholesterol lowering by pharmacological intervention prevents atherosclerotic plaque progression and has been shown ...
  • Pharmacoepidemiological studies of breast and colorectal cancer: The association between statins and cancer outcomes 

    SMITH, AMELIA (Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)
    Breast and colorectal cancer are two of the most commonly diagnosed cancers in Ireland and worldwide, and a significant cause of cancer deaths. Statins, which are drugs that are commonly used in the prevention of ...
  • Pharmacoepidemiology of diabetes mellitus in a national population 

    Zaharan, Nur Lisa (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)
    Diabetes is associated with significant morbidity and mortality from microvascular and macrovascular complications. It is projected that the prevalence of diabetes will increase worldwide especially in the elderly population ...
  • The Pharmacokinetic Interaction between Ivacaftor and Ritonavir 

    LIDDY, ANNE MARIE (Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)
    Ivacaftor is the first small molecule for the treatment of cystic fibrosis (CF) that directly targets the inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In phase III clinical trials ...
  • Pharmacokinetics of selected antiretroviral and antimalarial drugs in Ugandan adults 

    Byakika-Kibwika, Pauline (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)
    Human immunodeficiency virus (HIV) and malaria are two major infectious diseases causing significant morbidity and mortality worldwide. The two have overlapping geographical distribution in sub-Saharan Africa, where over ...
  • Pharmacologically induced long-term enhancement in the hippocampus in vivo 

    Hayes, Jennifer (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2007)
    The present study investigated the mechanisms underlying a pharmacologically induced long-term enhancement (LTE) of fast excitatory synaptic transmission in the CA1 region of the rat hippocampus in vivo. The role of ...
  • Prescribing for institutionalised older people 

    Flint, Helen Mary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)
    Introduction: In order to investigate aspects of prescribing practice and drug administration in institutionalised older people, the following aims for the study were developed; -- To compare prescribing practices between ...
  • Prescription refill models of medication taking behaviour 

    Barron, T. Ian (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)
    Medication taking can be defined in terms of two separate and distinct behaviours; adherence and persistence. These behaviours represent the ways in which a patient may take a treatment correctly; namely, acting in accordance ...
  • Prostate cancer pharmacoepidemiology : digoxin, aspirin and patient outcomes 

    Flahavan, Eva (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)
    Pharmacoepidemiology is the study of the effects of medicines in a real-world population; combining pharmacology, the study of medicines, with epidemiology the study of diseases. Prostate cancer is the most commonly diagnosed ...
  • Regulation of expression of transcription factors nuclear factor-kappa B and early growth response-1 by Helicobacter pylori 

    Abdel-Latif, Mohamed Mahmoud Mohamed (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    The Gram-negative bacterium Helicobacter pylori colonizes the human gastric epithelium and is a causative agent of peptic ulcer disease and gastric adenocarcinoma. Although H. pylori colonization is associated with gastric ...
  • Risk markers for acute stroke in Ireland - association of sodium-lithium countertransport (SLC) with vascular disease 

    Collins, Daniel Ronan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    The work in this thesis is divided into two parts, an epidemiological study of the risk markers for stroke in an Irish population and a laboratory study of the possible association between sodium lithium countertransport ...
  • Stress and long-term potentiation 

    Shakesby, Alison (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)
    Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ...
  • Structural remodelling of the vascular wall in relation to ageing and arterial stiffening 

    McNulty, Marie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    Structural remodelling of the vascular wall has been investigated in this study in terms of ageing and the process of vascular stiffening. While common structural adaptations are often presumed for ageing and vascular ...
  • Synaptic plasticity in animal models of stress : serotonergic mechanisms 

    Ryan, Benedict K. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)
    The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ...