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Now showing items 30-41 of 41

  • Pharmacologically induced long-term enhancement in the hippocampus in vivo 

    Hayes, Jennifer (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2007)
    The present study investigated the mechanisms underlying a pharmacologically induced long-term enhancement (LTE) of fast excitatory synaptic transmission in the CA1 region of the rat hippocampus in vivo. The role of ...
  • Prescribing for institutionalised older people 

    Flint, Helen Mary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)
    Introduction: In order to investigate aspects of prescribing practice and drug administration in institutionalised older people, the following aims for the study were developed; -- To compare prescribing practices between ...
  • Prescription refill models of medication taking behaviour 

    Barron, T. Ian (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)
    Medication taking can be defined in terms of two separate and distinct behaviours; adherence and persistence. These behaviours represent the ways in which a patient may take a treatment correctly; namely, acting in accordance ...
  • Prostate cancer pharmacoepidemiology : digoxin, aspirin and patient outcomes 

    Flahavan, Eva (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)
    Pharmacoepidemiology is the study of the effects of medicines in a real-world population; combining pharmacology, the study of medicines, with epidemiology the study of diseases. Prostate cancer is the most commonly diagnosed ...
  • Regulation of expression of transcription factors nuclear factor-kappa B and early growth response-1 by Helicobacter pylori 

    Abdel-Latif, Mohamed Mahmoud Mohamed (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    The Gram-negative bacterium Helicobacter pylori colonizes the human gastric epithelium and is a causative agent of peptic ulcer disease and gastric adenocarcinoma. Although H. pylori colonization is associated with gastric ...
  • Risk markers for acute stroke in Ireland - association of sodium-lithium countertransport (SLC) with vascular disease 

    Collins, Daniel Ronan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    The work in this thesis is divided into two parts, an epidemiological study of the risk markers for stroke in an Irish population and a laboratory study of the possible association between sodium lithium countertransport ...
  • Stress and long-term potentiation 

    Shakesby, Alison (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)
    Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ...
  • Structural remodelling of the vascular wall in relation to ageing and arterial stiffening 

    McNulty, Marie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    Structural remodelling of the vascular wall has been investigated in this study in terms of ageing and the process of vascular stiffening. While common structural adaptations are often presumed for ageing and vascular ...
  • Synaptic plasticity in animal models of stress : serotonergic mechanisms 

    Ryan, Benedict K. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)
    The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ...
  • The influence of antiviral therapy and HIV / HCV proteins on matrix metalloproteinase and cytokine production : an in vitro and in vivo study 

    Kennedy, Alan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)
    The effect of antiviral therapy on MMP/TIMP expression in THP-1 and LX-2 cells and in HIV/HCV co-infected patients: MMP-9 activity was measured by gelatin zymography, MMP-9 mRNA expression by real-time RT PCR, and MMP-9, ...
  • The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland 

    Williams, David (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)
    Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ...
  • β-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts 

    Rietz, Anne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)
    Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 μM) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after ...