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  • Altered endotoxin responsiveness in healthy children with Down syndrome. 

    Roche, Edna; Doherty, Derek; Leahy, Ronan; Molloy, Eleanor; Balfe, Joanne (2018)
    Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ...
  • Increased systemic inflammation in children with Down syndrome 

    Molloy, Eleanor; Roche, Edna; Leahy, Ronan; Doherty, Derek; Franklin, Orla; Balfe, Joanne; Kelly, Lynne (2020)
    Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. Cytokine dysregulation may underpin these clinical sequelae ...