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dc.contributor.authorRomero-Ortuno, Romanen
dc.contributor.authorKnight, Silvinen
dc.contributor.authorKenny, Roseen
dc.contributor.authorO'Halloran, Aislingen
dc.date.accessioned2022-12-10T14:01:25Z
dc.date.available2022-12-10T14:01:25Z
dc.date.issued2022en
dc.date.submitted2022en
dc.identifier.citationEoin Duggan, Caoileann H. Murphy, Silvin P. Knight, James R.C. Davis, Aisling M. O?Halloran, Rose Anne Kenny, Roman Romero-Ortuno, Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing, Journal of Gerontology: Medical Sciences, 2022en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/101854
dc.descriptionPUBLISHEDen
dc.description.abstractBackground: Sarcopenia and orthostatic hypotension are growing age-related health burdens associated with adverse outcomes including falls. Despite a possible pathophysiological link, the association between the two disorders is not well elucidated. We sought to investigate this relationship in The Irish Longitudinal Study on Ageing (TILDA). Methods: Data from 2,858 participants at wave 3 of TILDA were analyzed. Probable sarcopenia was defined as per the European Working Group on Sarcopenia in Older People revised definition cut-offs (hand grip strength (HGS) < 27kg in men, <16kg in women and/or five-chair stand test (5CST) time >15s). Participants underwent an active stand orthostatic test with continuous blood pressure (BP) monitoring. Multi-level mixed effects models, controlling for possible confounders, were used to assess the effect of probable sarcopenia by HGS and 5CST criteria on the change in BP after standing. Results: HGS- and 5CST-defined probable sarcopenia were independently associated with an attenuated BP recovery at 10-20s post-stand (systolic BP: β -0.54, P<0.001; β -0.25, P<0.001). On average, those meeting HGS probable sarcopenia criteria had a significantly lower BP at 20, 30 and 40s (differences in systolic BP: -5.01mmHg, -3.68mmHg, -2.32mmHg, P<0.05 for all). Those meeting 5CST probable sarcopenia criteria had a significant difference in systolic BP at 20s (-1.94mmHg, P=0.002) but not at 30 or 40s. Conclusions: Probable sarcopenia had a significant association with delayed orthostatic blood pressure recovery, with HGS-defined probable sarcopenia having a stronger association than 5CST-defined probable sarcopenia. Results support a modest but significant pathophysiological link between probable sarcopenia and orthostatic hypotension.en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Gerontology: Medical Sciencesen
dc.rightsYen
dc.subject5 chair stands testen
dc.subjectGrip strengthen
dc.subjectOrthostatic hypotensionen
dc.subjectSarcopeniaen
dc.titleDifferential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageingen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/romerooren
dc.identifier.peoplefinderurlhttp://people.tcd.ie/aiohalloen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/siknighten
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rkennyen
dc.identifier.rssinternalid248791en
dc.identifier.doihttps://doi.org/10.1093/gerona/glac243en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber18/FRL/6188en
dc.subject.TCDThemeAgeingen
dc.identifier.orcid_id0000-0002-3882-7447en
dc.subject.darat_impairmentAge-related disabilityen
dc.subject.darat_impairmentChronic Health Conditionen
dc.subject.darat_thematicHealthen
dc.subject.darat_thematicThird age/ageingen
dc.status.accessibleNen


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